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Soybeans soaked in warm water naturally release key cancer-fighting substance

Date:
May 9, 2012
Source:
American Chemical Society
Summary:
Soybeans soaking in warm water could become a new "green" source for production of a cancer-fighting substance now manufactured in a complicated and time-consuming industrial process, scientists are reporting.
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Soybeans.
Credit: © CocitaPhotography / Fotolia

Soybeans soaking in warm water could become a new "green" source for production of a cancer-fighting substance now manufactured in a complicated and time-consuming industrial process, scientists are reporting in ACS' Journal of Agricultural and Food Chemistry.

Hari B. Krishnan and colleagues explain that the substance, Bowman-Birk Protease Inhibitor (BBI), has shown promise for preventing certain forms of cancer in clinical trials. Those human tests resulted from evidence of BBI's beneficial effects, including indications that BBI derived from the large amounts of soybeans in traditional Japanese diets might underpin low cancer mortality rates in Japan. However, the current method of extracting BBI from soybeans is time-consuming and involves harsh chemicals. The scientists set out to see if there might be a greener and more environmentally friendly way of obtaining BBI.

They found that soybean seeds incubated in water at 122 degrees Fahrenheit naturally release large amounts of BBI that can easily be harvested from the water. The protein appeared to be active, with tests showing that it stopped breast cancer cells from dividing in a laboratory dish. "The abundance of BBI in soybean seed exudates by incubating the seeds in warm water provides a simple and alternative method to isolate this low molecular weight protein," the researchers said.

The scientists acknowledge funding from the Agricultural Research Service of the U.S. Department of Agriculture.


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The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Manoj H. Palavalli, Savithiry S. Natarajan, Thomas T. Y. Wang, Hari B. Krishnan. Imbibition of Soybean Seeds in Warm Water Results in the Release of Copious Amounts of Bowman–Birk Protease Inhibitor, a Putative Anticarcinogenic Agent. Journal of Agricultural and Food Chemistry, 2012; 60 (12): 3135 DOI: 10.1021/jf205308w

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American Chemical Society. "Soybeans soaked in warm water naturally release key cancer-fighting substance." ScienceDaily. ScienceDaily, 9 May 2012. <www.sciencedaily.com/releases/2012/05/120509123858.htm>.
American Chemical Society. (2012, May 9). Soybeans soaked in warm water naturally release key cancer-fighting substance. ScienceDaily. Retrieved May 29, 2015 from www.sciencedaily.com/releases/2012/05/120509123858.htm
American Chemical Society. "Soybeans soaked in warm water naturally release key cancer-fighting substance." ScienceDaily. www.sciencedaily.com/releases/2012/05/120509123858.htm (accessed May 29, 2015).

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