Dr. Darja Marolt, an Investigator at The New York Stem Cell Foundation (NYSCF) Laboratory, is lead author on a study showing that human embryonic stem cells can be used to grow bone tissue grafts for use in research and potential therapeutic application. Dr. Marolt conducted this research as a post-doctoral NYSCF -- Druckenmiller Fellow at Columbia University in the laboratory of Dr. Gordana Vunjak- Novakovic.
The study, published in the early online edition of Proceedings of the National Academy of Sciences during the week of May 14th, is the first example of using bone cell progenitors derived from human embryonic stem cells to grow compact bone tissue in quantities large enough to repair centimeter-sized defects. When implanted in mice and studied over time, the implanted bone tissue supported blood vessel ingrowth, and continued development of normal bone structure, without demonstrating any incidence of tumor growth.
Dr. Marolt's work is a significant step forward in using pluripotent stem cells to repair and replace bone tissue in patients. Bone replacement therapies are relevant in treating patients with a variety of conditions, including wounded military personnel, patients with birth defects, or patients who have suffered other traumatic injury.
Since conducting this work as proof of principle at Columbia University, Dr. Marolt has continued to build upon this research as an Investigator in the NYSCF Laboratory, developing bone grafts from induced pluripotent stem (iPS) cells. iPS cells are similar to embryonic stem cells in that they can also give rise to nearly any type of cell in the body, but iPS cells are produced from adult cells and as such are individualized to each patient. By using iPS cells rather than embryonic stem cells to engineer tissue, Dr. Marolt hopes to develop personalized bone grafts that will avoid immune rejection and other implant complications.
The New York Stem Cell Foundation has supported Dr. Marolt's research throughout her career, first through a NYSCF -- Druckenmiller Fellowship to fund her post-doctoral work at Columbia University, and now with a NYSCF -- Helmsley Investigator Award at The New
York Stem Cell Foundation Laboratory. "The continuity of funding provided by NYSCF has allowed me to continue my research uninterrupted, making progress more quickly than would have otherwise been possible," Dr. Marolt said.
- Darja Marolt, Iván Marcos Campos, Sarindr Bhumiratana, Ana Koren, Petros Petridis, Geping Zhang, Patrice F. Spitalnik, Warren L. Grayson, and Gordana Vunjak-Novakovic. Engineering bone tissue from human embryonic stem cells. Proceedings of the National Academy of Sciences, May 14, 2012 DOI: 10.1073/pnas.1201830109
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