Featured Research

from universities, journals, and other organizations

New process would make anti-malarial drug less costly

Date:
May 23, 2012
Source:
American Chemical Society
Summary:
Scientists are reporting development of a new, higher-yield, two-step, less costly process that may ease supply problems and zigzagging prices for the raw material essential for making the mainstay drug for malaria. That disease sickens 300-500 million people annually and kills more than one million. The report on the process uses readily available substances and could be easily implemented by drug companies.

Scientists are reporting development of a new, higher-yield, two-step, less costly process that may ease supply problems and zigzagging prices for the raw material essential for making the mainstay drug for malaria. That disease sickens 300-500 million people annually and kills more than 1 million.

The report on the process, which uses readily available substances and could be easily implemented by drug companies, appears in ACS' journal Organic Process Research & Development.

David Teager and Rodger Stringham of the Clinton Health Access Initiative explain that artemisinin combination therapy (ACT) is the most effective treatment for malaria, a parasitic infection that is transferred to humans from the bite of an infected mosquito. Artemisinin, which is used to produce the key ingredient in ACT, comes from Artemisia annua, a medicinal plant grown in China. In recent years, the price for artemisinin has undergone huge market fluctuations, ranging from about $180 to $410 per pound, due to weather conditions and the demand for ACT. Keeping costs down is important because most cases of malaria occur in developing areas in the tropics and subtropics.

The researchers reasoned that one way to help stabilize prices would be to improve the current ACT manufacturing process, which consistently yields less of the ingredient than expected. That improvement would reduce the amount of Artemisia annua needed to make ACT.

The new process is much simpler and generates less potentially hazardous waste than the current method. It also reduced the amount of artemisinin required to make ACT, which makes the process less costly. A "semisynthetic" version of artemisinin also worked well as a starting material in the new method. "We are in the process of sharing this procedure with manufacturing partners in our global fight to combat malaria," say the researchers.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rodger W. Stringham, David S. Teager. Streamlined Process for the Conversion of Artemisinin to Artemether. Organic Process Research & Development, 2012; 16 (5): 764 DOI: 10.1021/op300037e

Cite This Page:

American Chemical Society. "New process would make anti-malarial drug less costly." ScienceDaily. ScienceDaily, 23 May 2012. <www.sciencedaily.com/releases/2012/05/120523115049.htm>.
American Chemical Society. (2012, May 23). New process would make anti-malarial drug less costly. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2012/05/120523115049.htm
American Chemical Society. "New process would make anti-malarial drug less costly." ScienceDaily. www.sciencedaily.com/releases/2012/05/120523115049.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins