Featured Research

from universities, journals, and other organizations

Male fertility genes discovered

Date:
May 24, 2012
Source:
Cell Press
Summary:
A new study has revealed previously undiscovered genetic variants that influence fertility in men. The findings shed much-needed light on human reproduction and might provide answers for countless men suffering from infertility.

A new study has revealed previously undiscovered genetic variants that influence fertility in men. The findings, published by Cell Press on May 24th in the American Journal of Human Genetics, shed much-needed light on human reproduction and might provide answers for countless men suffering from infertility.

Related Articles


Despite its high incidence, infertility remains a sensitive topic. Some of the stigma surrounding infertility arises from a lack of known scientific causes. In fact, nearly a quarter of reported infertility cases remain unexplained. Research regarding the genetics of fertility has come primarily from studies involving infertile subjects. "Such studies have not been able to identify genes or pathways contributing to variation in natural human fertility," remarks Carole Ober, the lead author of the study. This is because numerous non-genetic factors, such as alcohol and tobacco use, certain medications, and disease history, can contribute to infertility.

Ober and her graduate student, Gülüm Kosova, at the University of Chicago have taken a different approach. By studying a founder population, the Hutterites, Ober's research maximizes genetic influences and minimizes non-genetic ones. The Hutterites are a branch of Anabaptists who conscribe to a common set of religious and social beliefs. "Hutterites [forbid] contraception and uniformly desire large families, providing an outstanding population in which to study the genetics of normal human fertility," explains Ober. Rather than studying infertile subjects, the team included Hutterite men who had one or more child, and it took both family size and birth rate into consideration.

The study uncovered more than 40 genetic regions that influence fertility in Hutterite men. Nine of these regions were additionally found to impact sperm quality in non-Hutterites. These regions harbor genes involved in several essential biological processes, including protein regulation, nucleotide binding, and immunity, and shed light on the complexity of human fertility. Ultimately, says Ober, further studies might find that mutations in these genes underlie some of the currently unexplained cases of male infertility.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. gülüm Kosova, Nicole M. Scott, Craig Niederberger, Gail S. Prins and Carole Ober. Genome-wide Association Study Identifies Candidate Genes for Male Fertility Traits in Humans. American Journal of Human Genetics, 2012 DOI: 10.1016/j.ajhg.2012.04.016

Cite This Page:

Cell Press. "Male fertility genes discovered." ScienceDaily. ScienceDaily, 24 May 2012. <www.sciencedaily.com/releases/2012/05/120524123013.htm>.
Cell Press. (2012, May 24). Male fertility genes discovered. ScienceDaily. Retrieved November 21, 2014 from www.sciencedaily.com/releases/2012/05/120524123013.htm
Cell Press. "Male fertility genes discovered." ScienceDaily. www.sciencedaily.com/releases/2012/05/120524123013.htm (accessed November 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN Says It Will Scale Up Its Ebola Response

UN Says It Will Scale Up Its Ebola Response

AFP (Nov. 20, 2014) — UN Resident Coordinator David McLachlan-Karr and WHO representative in the country Daniel Kertesz updated the media on the UN Ebola response on Wednesday. Duration: 00:51 Video provided by AFP
Powered by NewsLook.com
Takata Offers "sincerest Condolences" To Victims of Malfunctioning Airbag

Takata Offers "sincerest Condolences" To Victims of Malfunctioning Airbag

Reuters - US Online Video (Nov. 20, 2014) — U.S. Congress hears from a victim and company officials as it holds a hearing on the safety of Takata airbags after reports of injuries. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Obesity Costs Almost As Much As War And Terrorism

Obesity Costs Almost As Much As War And Terrorism

Newsy (Nov. 20, 2014) — The newest estimate of the cost of obesity is pretty jarring — $2 trillion. But how did researchers get to that number? Video provided by Newsy
Powered by NewsLook.com
Calling All Men: Here's Your Chance to Experience Labor Pains

Calling All Men: Here's Your Chance to Experience Labor Pains

Reuters - Light News Video Online (Nov. 20, 2014) — Chinese hospital offers men a chance to experience the pain of child birth via electric shocks. Sharon Reich reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins