Featured Research

from universities, journals, and other organizations

Researchers identify changes in cholesterol metabolic pathways

Date:
June 7, 2012
Source:
Virginia Commonwealth University
Summary:
A new study has identified molecular changes responsible for abnormal cholesterol production and metabolism in the livers of patients with a common liver condition, and these changes may explain the severity of a patient’s liver disease and risks to their heart health.

A new study from the Virginia Commonwealth University School of Medicine has identified molecular changes responsible for abnormal cholesterol production and metabolism in the livers of patients with a common liver condition, and these changes may explain the severity of a patient's liver disease and risks to their heart health.

It is estimated that a third of Americans have a fatty liver. Nonalcoholic fatty liver disease is a very common liver condition. Nonalcoholic steatohepatitis, or NASH, the more aggressive form of nonalcoholic fatty liver disease, is associated with increased cardiac risk and liver-related mortality.

The VCU findings may provide researchers with potential new targets for treatment and also allow clinicians to further refine how they assess cardiovascular risk and develop ways to reduce it in individuals with a more aggressive form of nonalcoholic fatty liver disease called nonalcoholic steatohepatitis, or NASH.

In the study, published in the May issue of Cell Metabolism, the team has shown that there is not only increased production of cholesterol but a decreased expression of the receptor that takes up cholesterol from the blood. This would be expected to both enhance cholesterol output from the liver and reduce its removal, thereby making it more available to enter blood vessels and contribute to cardiovascular disease. The liver not only makes cholesterol, but also takes up cholesterol from the blood.

"This indicates that there is excessive cholesterol production in the liver when one develops fatty liver disease," said lead investigator Arun Sanyal, M.D., professor and chair in the Division of Gastroenterology, Hepatology and Nutrition in the VCU School of Medicine.

"This may be important both to drive the disease towards cirrhosis and to increase the risks of heart disease in those with fatty liver disease," said Sanyal.

Sanyal collaborated with VCU colleagues in the VCU Division of Gastroenterology, Hepatology and Nutrition, the Department of Surgery and the Department of Pathology.

The work was supported in part by grants from the National Institutes of Health, grant numbers: 5R01DK081410-03, K24 DK 02755 and T32 DK-007150-33.


Story Source:

The above story is based on materials provided by Virginia Commonwealth University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hae-Ki Min, Ashwani Kapoor, Michael Fuchs, Faridoddin Mirshahi, Huiping Zhou, James Maher, John Kellum, Russell Warnick, MelissaJ. Contos, ArunJ. Sanyal. Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease. Cell Metabolism, 2012; 15 (5): 665 DOI: 10.1016/j.cmet.2012.04.004

Cite This Page:

Virginia Commonwealth University. "Researchers identify changes in cholesterol metabolic pathways." ScienceDaily. ScienceDaily, 7 June 2012. <www.sciencedaily.com/releases/2012/06/120607175819.htm>.
Virginia Commonwealth University. (2012, June 7). Researchers identify changes in cholesterol metabolic pathways. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2012/06/120607175819.htm
Virginia Commonwealth University. "Researchers identify changes in cholesterol metabolic pathways." ScienceDaily. www.sciencedaily.com/releases/2012/06/120607175819.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins