Featured Research

from universities, journals, and other organizations

Liquid glucagon formulation discovered for potential use in artificial pancreas systems

Date:
June 12, 2012
Source:
JDRF
Summary:
Medical researchers have discovered a liquid glucagon formulation that may be useable in standard diabetes pumps. Such a formulation could broaden the use of glucagon to help prevent hypoglycemia in people with Type 1 diabetes who are treated with insulin. It could also open a path to future-generation artificial pancreas systems that dispense more than just insulin for optimizing glucose control.

JDRF-funded researchers at Oregon Health & Science University (OHSU) and Legacy Health have discovered a liquid glucagon formulation that may be useable in standard diabetes pumps. Such a formulation could broaden the use of glucagon to help prevent hypoglycemia in people with type 1 diabetes (T1D) who are treated with insulin. It could also open a path to future-generation artificial pancreas systems that dispense more than just insulin for optimizing glucose control.

"Our previous studies have shown that the injections of small amounts of glucagon prevent hypoglycemia, which is a frequent and serious complication of type 1 diabetes that can lead to seizures, loss of consciousness, and even death," said W. Kenneth Ward, M.D., associate professor of medicine (endocrinology, diabetes, and clinical nutrition) at OHSU School of Medicine and senior scientist at Legacy Health, the two Portland, OR-based organizations that collaborated on the study. The research was presented at the American Diabetes Association's (ADA) 72nd Scientific Sessions on June 8, and on June 10, in Philadelphia.

Dr. Ward continues: "Current forms of glucagon cannot be kept for long periods of time in a portable pump, and therefore could not be used as part of an artificial pancreas system. While it is important to note that additional studies will be undertaken in animals and humans before FDA approval can be sought, we have found that the alkaline glucagon compound we discovered can be kept in liquid form for long periods of time, potentially opening pathways for use in bi-hormonal diabetes pumps and toward better therapies for people with diabetes."

The research is a key step forward toward the routine delivery of glucagon for people with T1D, and toward the development of a multi-hormonal, fully-automated closed loop artificial pancreas system. Such future-generation artificial pancreas systems would automatically deliver both insulin and glucagon, or other drugs.

Glucagon is a naturally occurring hormone that responds to hypoglycemia (extreme low blood sugar) by raising blood sugars, but its regulation is impaired in people with T1D. It works to complement the function of insulin to provide the natural fine-tuning of blood glucose control. Previous studies have shown that the addition of glucagon to insulin treatment reduces the frequency of hypoglycemia in T1D, more closely mimicking the physiology of someone without diabetes.

Commercially available glucagon does not maintain its liquid form after the powder and solution are combined, making it suitable only for immediate use. Dr. Ward and his team found that raising the pH of the glucagon allowed the hormone to maintain liquid form, and concluded that this formulation could be suitable for use in a closed-loop bi-hormonal pump.

"We have seen very promising results in our studies of artificial pancreas systems that utilize both insulin and glucagon. But for people with diabetes to realize this potential benefit, we need glucagon that is stable and can be used in a pump," said Sanjoy Dutta, Ph.D., JDRF's senior director of treat therapies. "Dr. Ward's research is promising and steers us toward more tangible solutions along the path toward a multi-hormonal, fully-automated closed loop artificial pancreas."

The artificial pancreas combines a continuous glucose monitor (CGM) and an insulin pump via sophisticated computer software, to provide the right amount of insulin at the right times for people with diabetes. In March, the U.S. Food and Drug Administration approved the first artificial pancreas outpatient trial in the United States. Researchers envision future generations of the device to automatically deliver more than one hormone, in addition to insulin, to more closely perform the functions of a non-diabetic human pancreas.


Story Source:

The above story is based on materials provided by JDRF. Note: Materials may be edited for content and length.


Cite This Page:

JDRF. "Liquid glucagon formulation discovered for potential use in artificial pancreas systems." ScienceDaily. ScienceDaily, 12 June 2012. <www.sciencedaily.com/releases/2012/06/120612144813.htm>.
JDRF. (2012, June 12). Liquid glucagon formulation discovered for potential use in artificial pancreas systems. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2012/06/120612144813.htm
JDRF. "Liquid glucagon formulation discovered for potential use in artificial pancreas systems." ScienceDaily. www.sciencedaily.com/releases/2012/06/120612144813.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins