Featured Research

from universities, journals, and other organizations

Do you always have room for dessert? Blame ghrelin, study authors say

Date:
June 25, 2012
Source:
The Endocrine Society
Summary:
A new study suggests that the appetite-inducing hormone ghrelin increases the incentive for humans to eat high-calorie foods, even on a full stomach.

A new study suggests that the appetite-inducing hormone ghrelin increases the incentive for humans to eat high-calorie foods, even on a full stomach. The results were reported June 24 at The Endocrine Society's 94th Annual Meeting in Houston.

In the study, rats lacking the ghrelin receptor gene ate less of a sweet treat after a full meal than did rodents whose ghrelin receptor gene was intact.

"Combined with an increasingly sedentary lifestyle, overconsumption of reward-driven foods may be partly responsible for the current obesity epidemic," said Veronique St-Onge, a PhD candidate at Carleton University, Ottawa, Canada, and the study's lead investigator. "Ghrelin receptors may represent an important target for obesity treatments."

With the principal investigator, Alfonso Abizaid, PhD, of Carleton University, St-Onge studied the role of ghrelin -- the so-called "hunger hormone" -- in what they called the "dessert phenomenon": eating tasty desserts after a filling meal. To do so, they used a rat strain in which ghrelin signaling was genetically disrupted by "knockout" of the receptor gene. Specifically, the researchers compared the knockout rats' tendency to eat cookie dough after a meal, compared with that of the control rat strain (wild-type rats), which possessed an intact ghrelin receptor gene.

Each group consisted of 10 rats that were allowed free access to their regular rat chow for four hours each day -- 10 a.m. to 2 p.m. -- until they ate most of their usual daily intake. On the final day of the study, each rat was offered 30 grams (just over an ounce) of cookie dough during the last hour of feeding.

There was no difference between groups in the amounts of rat chow that they consumed. However, knockout rats ate slightly less cookie dough than the other rats did (6 versus 8 grams, or about 0.2 versus 0.3 ounces). This difference was statistically significant (P = .02) when compared by the amount eaten per grams of body weight, the authors reported.

"This result supports the idea that ghrelin is involved in reward-based feeding and delays the termination of a meal," St-Onge said. "A greater understanding of ghrelin's action may be useful for preventing obesity that results from overconsumption of rewarding foods."


Story Source:

The above story is based on materials provided by The Endocrine Society. Note: Materials may be edited for content and length.


Cite This Page:

The Endocrine Society. "Do you always have room for dessert? Blame ghrelin, study authors say." ScienceDaily. ScienceDaily, 25 June 2012. <www.sciencedaily.com/releases/2012/06/120625092502.htm>.
The Endocrine Society. (2012, June 25). Do you always have room for dessert? Blame ghrelin, study authors say. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2012/06/120625092502.htm
The Endocrine Society. "Do you always have room for dessert? Blame ghrelin, study authors say." ScienceDaily. www.sciencedaily.com/releases/2012/06/120625092502.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Costs Keep Mounting

Ebola Costs Keep Mounting

Reuters - Business Video Online (Sep. 23, 2014) The WHO has warned up to 20,000 people could be infected with Ebola over the next few weeks. As Sonia Legg reports, the implications for the West African countries suffering from the disease are huge. Video provided by Reuters
Powered by NewsLook.com
Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins