Featured Research

from universities, journals, and other organizations

Scientists find molecule to starve lung cancer and improve ventilator recovery

Date:
July 6, 2012
Source:
Federation of American Societies for Experimental Biology
Summary:
New research reveals a connection between sugar, cancer, and dependence on breathing machines -- microRNA-320a. Scientists show microRNA-320a as responsible for aiding glycolysis. Glycolysis, the process of converting sugar into energy, fuels some cancers and contributes to the wasting of unused muscles when people are using ventilators. Identifying ways to use microRNA-320a to starve tumors and keep unused muscles strong represents a therapeutic leap for numerous health conditions.

A new research report published online in the FASEB Journal reveals a connection among sugar, cancer, and dependence on breathing machines--microRNA-320a. In the report, Stanford scientists show that the molecule microRNA-320a is responsible for helping control glycolysis. Glycolysis is the process of converting sugar into energy, which fuels the growth of some cancers, and contributes to the wasting of unused muscles such as the diaphragm when people are using ventilators. Identifying ways to use microRNA-320a to starve tumors and keep unused muscles strong would represent a significant therapeutic leap for numerous diseases and health conditions.

Related Articles


"We hope that this discovery will yield a new avenue of molecular treatment for cancers, particularly lung cancer, which is the number one cause of cancer deaths worldwide," said Joseph B. Shrager, M.D., a researcher involved in the work who is a Professor of Cardiothoracic Surgery, and Chief of the Division of Thoracic Surgery at Stanford University School of Medicine, and VA Palo Alto Healthcare System in California. "We also hope it can lead to a treatment to be given to intensive care unit patients who require the breathing machine, reducing the length of time they require the machine, and thereby reducing complications and deaths."

To make this discovery, Shrager and colleagues studied lung cancer tissues from patients and tissue from the diaphragm (the primary muscle used for breathing) from patients who had been on a breathing machine for more than a few hours. They found that both types of tissue had increases in glycolysis, as well as reductions in a molecule that controls glycolysis -- microRNA-320a. Test tube experiments then showed that microRNA-320a definitely controls how much energy these two very different tissues have available to them.

"Just as the discovery of angiogenesis opened new doors to find ways to stop cancers and to help the body heal itself," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal, "this discovery, on a smaller scale, does the same by identifying an important molecule that may help starve tumors and help the body recover."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. H. Tang, M. Lee, O. Sharpe, L. Salamone, E. J. Noonan, C. D. Hoang, S. Levine, W. H. Robinson, J. B. Shrager. Oxidative stress-responsive microRNA-320 regulates glycolysis in diverse biological systems. The FASEB Journal, 2012; DOI: 10.1096/fj.11-197467

Cite This Page:

Federation of American Societies for Experimental Biology. "Scientists find molecule to starve lung cancer and improve ventilator recovery." ScienceDaily. ScienceDaily, 6 July 2012. <www.sciencedaily.com/releases/2012/07/120706164332.htm>.
Federation of American Societies for Experimental Biology. (2012, July 6). Scientists find molecule to starve lung cancer and improve ventilator recovery. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2012/07/120706164332.htm
Federation of American Societies for Experimental Biology. "Scientists find molecule to starve lung cancer and improve ventilator recovery." ScienceDaily. www.sciencedaily.com/releases/2012/07/120706164332.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins