Featured Research

from universities, journals, and other organizations

Gastric bypass surgery alters gut microbiota profile along the intestine

Date:
July 10, 2012
Source:
Society for the Study of Ingestive Behavior
Summary:
New research finds that gastric bypass surgery induces changes in the gut microbiota and peptide release that are similar to those seen after treatment with prebiotics.

Research to be presented at the Annual Meeting of the Society for the Study of Ingestive Behavior (SSIB) finds that gastric bypass surgery induces changes in the gut microbiota and peptide release that are similar to those seen after treatment with prebiotics.

Related Articles


Previous animal research demonstrated that ingestion of a high-fat diet produces weight gain and profoundly affects the gut microbiota composition, resulting in a greater abundance of one type of bacteria called Firmicutes, and a decrease in Bifidobacteria spp and Bacteroidetes. A similar pattern has also been found in obese humans. Feeding of prebiotics, substances that enhance the growth of beneficial bacteria, changes the composition and/or the activity of the gastrointestinal microbiota, to promote the release of gut peptides and to improve glucose and lipid metabolism in diet-induced obese and type 2 diabetic mice.

Roux-en-Y gastric bypass (RYGB) surgery is considered the most effective treatment of morbid obesity and diabetes. Recent studies reported substantial shifts in the composition of the gut microbiota towards lower concentrations of Firmicutes and increased Bacteroidetes in obese subjects after RYGB. Most of the human studies on gut microbiota have been carried out using fecal samples which may not accurately represent how RYGB surgery affects the gut microbiota profile along different parts of the intestine.

Because RYGB may affect how nutrients are absorbed in different portions of the intestine, a new study conducted by researchers at the University of Zurich measured the bacterial composition and the amounts of different peptides that affect food intake along different intestinal segments after RYGB in rats. They found that 14 weeks after surgery, Bifidobacteria spp, and Bacteroides-Prevotella spp content were significantly increased in several portions of the intestine in RYGB rats compared to control animals. In fact, the changes in gut microbe populations after RGYB resembled those seen after treatment with prebiotics. Gut microbiota changes were also associated with altered production of gastrointestinal hormones known to control energy balance.

The lead author on this study, Melania Osto, Ph.D. said "Our findings show that RYGB surgery leads to changes in gut microbiota that resemble those seen after treatment with prebiotics. The results of this study suggest that postsurgical gut microbiota modulations may influence gut peptide release and significantly contribute to the beneficial metabolic effects of RYGB surgery."


Story Source:

The above story is based on materials provided by Society for the Study of Ingestive Behavior. Note: Materials may be edited for content and length.


Cite This Page:

Society for the Study of Ingestive Behavior. "Gastric bypass surgery alters gut microbiota profile along the intestine." ScienceDaily. ScienceDaily, 10 July 2012. <www.sciencedaily.com/releases/2012/07/120710093810.htm>.
Society for the Study of Ingestive Behavior. (2012, July 10). Gastric bypass surgery alters gut microbiota profile along the intestine. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2012/07/120710093810.htm
Society for the Study of Ingestive Behavior. "Gastric bypass surgery alters gut microbiota profile along the intestine." ScienceDaily. www.sciencedaily.com/releases/2012/07/120710093810.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins