Featured Research

from universities, journals, and other organizations

How hosts recognize bacteria

Date:
July 20, 2012
Source:
Universität Duisburg-Essen
Summary:
We are surrounded by bacteria, viruses, fungi and parasites. The fact that we nevertheless do not fall prey to infections is thanks to certain cellular sensor molecules such as toll-like receptors (TLR), which recognize the molecular structure of pathogens and intercede by ensuring an often completely unnoticeable elimination of the invaders. Their immune-activating abilities were only detected in 1998, a discovery which was awarded with the Nobel Prize. Now scientists are examining the complex recognition of bacteria.

In the cell, TLR13 recognises the segment of bacterial ribosomal ribonucleic acid to which specific antibiotics such as Erythromycin also bind should the segment not have been altered by mutation or other modifications.
Credit: Image courtesy of Universität Duisburg-Essen

We are surrounded by bacteria, viruses, fungi and parasites. The fact that we nevertheless do not fall prey to infections is thanks to certain cellular sensor molecules such as toll-like receptors (TLR), which recognize the molecular structure of pathogens and intercede by ensuring an often completely unnoticeable elimination of the invaders. Their immune-activating abilities were only detected in 1998, a discovery which was awarded with the Nobel Prize. Now, an international research team led by Prof. Dr. Carsten Kirschning of the Institute of Medical Microbiology at the University hospital Essen and the University of Duisburg-Essen and PD Dr. Hubertus Hochrein is examining the complex recognition of bacteria.

Related Articles


Their findings have been published in the research journal Science.

Our innate immune system is clever. Certain structures, which are characteristic of many microorganisms are recognized via TLR which trigger the necessary inflammatory response. However, the situation can become dangerous: since this receptor system is so sensitive, the immune response to serious infections may be over-exaggerated and miss the mark. Blood poisoning and frequently septic shock is the result.

Thus, the experts decided to take a closer look at the host recognition of Staphylococcus and E.coli bacteria, often the main agents of blood poisoning. They established that in the cell, TLR13 recognises the segment of bacterial ribosomal ribonucleic acid to which specific antibiotics such as Erythromycin also bind should the segment not have been altered by mutation or other modifications. The concrete ribonucleic acid is referred as 23S rRNA. Animal and human ribosomes do not bind Erythromycin to their own 28S rRNA because its structure resembles that of the 23S rRNA of resistant bacteria.

The new findings are significant for the treatment of bacterial infections and gaining a greater understanding of antibiotic resistance. In addition, these findings may be of help in the therapy of immunological overreactions and lead to new vaccination strategies.

The study was conducted by an international research team led by Prof. Dr. Carsten Kirschning of the Institute of Medical Microbiology at the University hospital, University of Duisburg-Essen, PD Dr. Hubertus Hochrein of Bavarian Nordic in Martinsried, Prof. Dr. Stefan Bauer of the Institute of Immunology at the Philipps University of Marburg and Prof. Dr. Hermann Wagner of the Institute of Medical Microbiology, Immunology and Hygiene at the Technical University of Munich. Further collaborating scientists came from Munich, Switzerland and Japan.


Story Source:

The above story is based on materials provided by Universität Duisburg-Essen. Note: Materials may be edited for content and length.


Journal Reference:

  1. Marina Oldenburg, Anne Krüger, Ruth Ferstl, Andreas Kaufmann, Gernot Nees, Anna Sigmund, Barbara Bathke, Henning Lauterbach, Mark Suter, Stefan Dreher, Uwe Koedel, Shizuo Akira, Taro Kawai, Jan Buer, Hermann Wagner, Stefan Bauer, Hubertus Hochrein, and Carsten J. Kirschning. TLR13 Recognizes Bacterial 23S rRNA Devoid of Erythromycin Resistance–Forming Modification. Science, 19 July 2012 DOI: 10.1126/science.1220363

Cite This Page:

Universität Duisburg-Essen. "How hosts recognize bacteria." ScienceDaily. ScienceDaily, 20 July 2012. <www.sciencedaily.com/releases/2012/07/120720083020.htm>.
Universität Duisburg-Essen. (2012, July 20). How hosts recognize bacteria. ScienceDaily. Retrieved January 25, 2015 from www.sciencedaily.com/releases/2012/07/120720083020.htm
Universität Duisburg-Essen. "How hosts recognize bacteria." ScienceDaily. www.sciencedaily.com/releases/2012/07/120720083020.htm (accessed January 25, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Sunday, January 25, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Florida Might Legalize Black Bear Hunting

Florida Might Legalize Black Bear Hunting

Newsy (Jan. 24, 2015) — A string of black bear attacks has Florida officials considering lifting the ban on hunting the animals to control their population. Video provided by Newsy
Powered by NewsLook.com
Ebola Killing Large Portion Of Ape Population

Ebola Killing Large Portion Of Ape Population

Newsy (Jan. 23, 2015) — Experts estimate Ebola has wiped out one-third of the world&apos;s gorillas and chimpanzees. Video provided by Newsy
Powered by NewsLook.com
Controversy Shrouds Captive Killer Whale in Miami

Controversy Shrouds Captive Killer Whale in Miami

Reuters - Light News Video Online (Jan. 23, 2015) — Activists hope the National Oceanic and Atmospheric Agency (NOAA) will label killer whales endangered, allowing lawyers to sue a Miami aquarium to release an orca into the wild after 44 years. Jillian Kitchener reports. Video provided by Reuters
Powered by NewsLook.com
‘Healthy’ Foods That Surprisingly Pack on Pounds

‘Healthy’ Foods That Surprisingly Pack on Pounds

Buzz60 (Jan. 23, 2015) — Some &apos;healthy&apos; foods are actually fattening. Fitness and nutrition expert John Basedow (@JohnBasedow) shines a light on the sneaky foods like nuts, seeds, granola, trail mix, avocados, guacamole, olive oil, peanut butter, fruit juices and salads that are good for you...but not so much for your waistline. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins