Featured Research

from universities, journals, and other organizations

Sick from stress? Blame your mom… and epigenetics

Date:
July 31, 2012
Source:
Federation of American Societies for Experimental Biology
Summary:
If you're sick from stress, a new research report suggests that what your mother ate -- or didn't eat -- may be part of the cause.

New research suggests that choline supplementation in pregnant women lowers cortisol in the baby by changing epigenetic expression of genes involved in cortisol production.

If you're sick from stress, a new research report appearing in the August 2012 issue of The FASEB Journal suggests that what your mother ate -- or didn't eat -- may be part of the cause. The report shows that choline intake that is higher than what is generally recommended during pregnancy may improve how a child responds to stress. These improvements are the result of epigenetic changes that ultimately lead to lower cortisol levels. Epigenetic changes affect how a gene functions, even if the gene itself is not changed. Lowering cortisol is important as high levels of cortisol are linked to a wide range of problems ranging from mental health to metabolic and cardiovascular disorders.

"We hope that our data will inform the development of choline intake recommendations for pregnant women that ensure optimal fetal development and reduce the risk of stress-related diseases throughout the life of the child," said Marie A. Caudill, Ph.D., a researcher involved in the work from the Division of Nutritional Sciences and Genomics at Cornell University in Ithaca, New York.

To make this discovery, Caudill and colleagues conducted a 12-week study involving pregnant women in their third trimester who consumed either the control diet providing 480 mg choline per day, a level that approximates current dietary recommendations, or the treatment diet which provided 930 mg choline per day. Maternal blood, cord blood and placenta tissue were collected to measure the blood levels of cortisol, the expression levels of genes that regulate cortisol, and the number of methyl groups attached to the DNA of the cortisol regulating genes (the epigenetic changes). Those from mothers who consumed the higher levels of choline showed reduced levels of cortisol.

"Depending on the relationship, one's mother can either produce stress or relieve it," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This report shows that her effect on stress begins even before birth. The importance of choline cannot be overstated as we continue to unravel the role it plays in human health and development."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. X. Jiang, J. Yan, A. A. West, C. A. Perry, O. V. Malysheva, S. Devapatla, E. Pressman, F. Vermeylen, M. A. Caudill. Maternal choline intake alters the epigenetic state of fetal cortisol-regulating genes in humans. The FASEB Journal, 2012; 26 (8): 3563 DOI: 10.1096/fj.12-207894

Cite This Page:

Federation of American Societies for Experimental Biology. "Sick from stress? Blame your mom… and epigenetics." ScienceDaily. ScienceDaily, 31 July 2012. <www.sciencedaily.com/releases/2012/07/120731103037.htm>.
Federation of American Societies for Experimental Biology. (2012, July 31). Sick from stress? Blame your mom… and epigenetics. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2012/07/120731103037.htm
Federation of American Societies for Experimental Biology. "Sick from stress? Blame your mom… and epigenetics." ScienceDaily. www.sciencedaily.com/releases/2012/07/120731103037.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins