Featured Research

from universities, journals, and other organizations

Preparation of anti-tumor nanoparticles using tiger milk mushroom

Date:
August 6, 2012
Source:
The Hong Kong Polytechnic University
Summary:
Tapping into the power of natural ingredients for safer treatment is the next frontier in the battle against cancer. A recent breakthrough uses tiger milk mushroom to prepare anti-tumor nanoparticles is bringing us one step closer.

A polysaccharide-protein complex was found in Tiger Milk mushrooms from Africa, which can turn selenium into new cancer treatment.
Credit: Copyright : Hong Kong Polytechnic University

Tapping into the power of natural ingredients for safer treatment is the next frontier in the battle against cancer. A recent breakthrough from HKPolyU uses tiger milk mushroom to prepare anti-tumor nanoparticles is bringing us one step closer.

Cancer is a word dreaded by many. Many cancers are deadly and difficult to treat while conventional remedies such as chemotherapy often cause physical and emotional sides effects, giving struggling patients more harm just as the cancer. What if cancer-killing drugs can become more natural and in harmony with our body? Tapping into the power of natural ingredients for safer treatment is the next frontier in the battle against cancer. A recent breakthrough from PolyU's Department of Applied Biology and Chemical Technology using tiger milk mushroom to prepare anti-tumor nanoparticles is bringing us one step closer.

A natural compound found in mushrooms may hold the key to a new class of cancer drugs. In Tiger Milk mushrooms from Africa, Dr Wong Ka-hing, Associate Director of the Food Safety and Technology Research Centre, has discovered a polysaccharide-protein complex (PSP) which can turn selenium, a common nutrient, into new cancer therapy to benefit millions of breast cancer patients around the world.

Selenium is a trace mineral essential for good health. Health benefits include boosting immune systems against viral infections. Staple foods and vegetables in our diet such as rice, wheat, potatoes, broccolis and onions are great sources of antioxidant. In nano-size, selenium was found to have potent anti-cancer effect in the laboratory. However, efficacy diminished as the nanoparticles fell back into bigger aggregates which suppressed the up-take into cancer cells. Finding new ways or compounds to halt the rebinding process is harder than it seems. Literally, it is quite like searching for a needle in a haystack.

The use of mushroom PSP as stabilizing force is a significant breakthrough. Combined with cutting-edge nanotechnology, Dr Wong and his team successfully made selenium nanoparticles to destroy breast cancer cells. "Lab-test results were exciting. Our selenium nanoparticles were found to have remarkable inhibition effect on the growth of human breast cancer cells by triggering the cells into self-destruction. The next stage will be tests on animals," Dr Wong said.

The research is still in a very early phase. But if successful, it could lead to a new drug much less toxic and more reliable, capable of killing cancer cells while leaving healthy tissues unharmed, which could mean fewer agonizing side-effects, greater comfort and better chances of recovery. Dr Wong also planned on developing a dietary supplement as auxiliary cancer treatments.

Scientists around the world have been looking into the therapeutic value of produces such as fish oil, broccoli, cauliflower, cabbage, and green tea. For safe human consumption, a natural ingredient must be effective against cancer in low concentration. Dr Wong's work has advanced medicine with a working tool for boosting the effectiveness of natural cancer killing compounds.

"Mushroom PSP has striking effects on controlling selenium nanoparticles," Dr. Wong added, "and a better understanding of this mechanism may help us find the next suitable compounds and make better nano-medicines for a whole host of cancers." Tiger Milk, similar to Chinese mushrooms we have in dishes and soups mushroom, is a common foodstuff in Africa, and the groundbreaking biomedical research opens door to making cancer drug from 100% natural ingredients. The drug development process is equally natural and green because all it takes are room temperature and water, which is little waste and without much power consumption.

Holding new promise for beating cancer, this research has won Dr Wong the Young Investigator Award at the 2011 International Conference of Food Factors and the Gold Medal in 40th International Exhibition of Inventions of Geneva.


Story Source:

The above story is based on materials provided by The Hong Kong Polytechnic University. Note: Materials may be edited for content and length.


Cite This Page:

The Hong Kong Polytechnic University. "Preparation of anti-tumor nanoparticles using tiger milk mushroom." ScienceDaily. ScienceDaily, 6 August 2012. <www.sciencedaily.com/releases/2012/08/120806125657.htm>.
The Hong Kong Polytechnic University. (2012, August 6). Preparation of anti-tumor nanoparticles using tiger milk mushroom. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2012/08/120806125657.htm
The Hong Kong Polytechnic University. "Preparation of anti-tumor nanoparticles using tiger milk mushroom." ScienceDaily. www.sciencedaily.com/releases/2012/08/120806125657.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins