Featured Research

from universities, journals, and other organizations

Potential hurdle to universal flu vaccine development may be overcome, study suggests

Date:
August 15, 2012
Source:
NIH/National Institute of Allergy and Infectious Diseases
Summary:
In the quest for a universal influenza vaccine -- one that elicits broadly neutralizing antibodies that can protect against most or all strains of flu virus -- scientists have faced a sobering question: Does pre-existing immunity generated by prior exposure to influenza virus or vaccine hamper production of broadly neutralizing antibodies? If so, then a universal flu vaccine might work best (and perhaps only) in very young children who have had limited exposure to influenza viruses or vaccines.

In the quest for a universal influenza vaccine -- one that elicits broadly neutralizing antibodies that can protect against most or all strains of flu virus -- scientists have faced a sobering question: Does pre-existing immunity generated by prior exposure to influenza virus or vaccine hamper production of broadly neutralizing antibodies? If so, then a universal flu vaccine might work best (and perhaps only) in very young children who have had limited exposure to influenza viruses or vaccines.

Now, in studies using mice and ferrets, investigators from the Vaccine Research Center (VRC) at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have shown that broadly neutralizing influenza antibodies can indeed be elicited by a prime-boost vaccine regimen, even when the animals had pre-existing immunity to influenza.

The vaccine regimen consisted of a DNA vaccine prime followed by boosting with an inactivated seasonal vaccine. It did not matter if the pre-existing immunity was due to exposure to a flu virus or if it followed vaccination with standard seasonal influenza vaccine. Influenza-immune ferrets inoculated with the prime-boost regimen were protected against challenge with unmatched influenza virus strains. If the same effect is found in studies in people, it might be possible to develop vaccines that give long-lasting flu protection to people of all ages, according to the researchers.

Several clinical trials to examine the ability of first-generation universal flu vaccines to generate broadly neutralizing antibodies are either under way or planned at the VRC.


Story Source:

The above story is based on materials provided by NIH/National Institute of Allergy and Infectious Diseases. Note: Materials may be edited for content and length.


Journal Reference:

  1. C.-J. Wei, H. M. Yassine, P. M. McTamney, J. G. D. Gall, J. R. R. Whittle, J. C. Boyington, G. J. Nabel. Elicitation of Broadly Neutralizing Influenza Antibodies in Animals with Previous Influenza Exposure. Science Translational Medicine, 2012; 4 (147): 147ra114 DOI: 10.1126/scitranslmed.3004273

Cite This Page:

NIH/National Institute of Allergy and Infectious Diseases. "Potential hurdle to universal flu vaccine development may be overcome, study suggests." ScienceDaily. ScienceDaily, 15 August 2012. <www.sciencedaily.com/releases/2012/08/120815142046.htm>.
NIH/National Institute of Allergy and Infectious Diseases. (2012, August 15). Potential hurdle to universal flu vaccine development may be overcome, study suggests. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2012/08/120815142046.htm
NIH/National Institute of Allergy and Infectious Diseases. "Potential hurdle to universal flu vaccine development may be overcome, study suggests." ScienceDaily. www.sciencedaily.com/releases/2012/08/120815142046.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins