Featured Research

from universities, journals, and other organizations

Study attempts to reverse autoimmunity in type 1 diabetes

Date:
August 23, 2012
Source:
Immune Tolerance Network
Summary:
Results from a novel experimental therapy for type 1 diabetes that boosts parts of the healthy immune system were just reported.

Results from a novel experimental therapy for Type 1 diabetes that boosts parts of the healthy immune system are reported August 23 in the scientific journal Diabetes. The trial was led by Carla Greenbaum, MD, Diabetes Research Program director at Benaroya Research Institute at Virginia Mason (BRI), and sponsored by the Immune Tolerance Network (ITN), a clinical trial network funded by the National Institutes of Health. The trial took a unique two-pronged approach to treating Type 1diabetes in newly diagnosed participants. Two drugs were administered in combination. One drug interferes with the immune response that causes Type 1 diabetes while a second drug simultaneously boosted the part of the immune response that usually regulates overactive immune cells.

Over 1 million people in the United States have Type 1 diabetes and the incidence is growing. In this disease, the body's immune system attacks and destroys the insulin-producing cells in the pancreas, called beta cells. However, at the time of diagnosis with Type 1 diabetes, a small number of beta cells may remain active in many individuals. Since even small amounts of natural insulin production can decrease the long-term effects of diabetes, therapies that attempt to rescue these remaining cells are badly needed.

In the clinical research trial, the combination of the two drugs Proleukin (IL-2) and Rapamune (sirolimus) were administered to see whether the drugs would affect the immune system to halt the autoimmune destruction of the remaining beta cells. The authors of the study describe successful boosting of regulatory components of the immune system in all nine subjects treated in the trial. However, other elements of the immune system also were expanded that were not anticipated. The temporary impairment of beta cell function led the authors to conclude that this drug combination was not having the desired overall effect. Monitoring of the insulin production in the nine subjects indicated that the beta cell preservation goal was not achieved, and the study was therefore stopped. "This study result has been extremely important to scientists looking for ways to stop the immune attack," says Dr. Greenbaum. "Our aim would be to harness the good effects of this therapy while preventing the bad effects." Participants who haven't yet completed the study will continue to be followed.

"The clinical and mechanistic findings from this study can help guide future treatments that boost good immunity," says Gerald Nepom, MD, PhD, Director of ITN. "This was an important clinical trial that will improve the design of subsequent trials to rescue beta cells in Type 1 diabetes."


Story Source:

The above story is based on materials provided by Immune Tolerance Network. Note: Materials may be edited for content and length.


Cite This Page:

Immune Tolerance Network. "Study attempts to reverse autoimmunity in type 1 diabetes." ScienceDaily. ScienceDaily, 23 August 2012. <www.sciencedaily.com/releases/2012/08/120823084625.htm>.
Immune Tolerance Network. (2012, August 23). Study attempts to reverse autoimmunity in type 1 diabetes. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2012/08/120823084625.htm
Immune Tolerance Network. "Study attempts to reverse autoimmunity in type 1 diabetes." ScienceDaily. www.sciencedaily.com/releases/2012/08/120823084625.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Quintuplets Head Home

Texas Quintuplets Head Home

Reuters - US Online Video (Aug. 1, 2014) After four months in the hospital, the first quintuplets to be born at Baylor University Medical Center head home. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Patient Coming to U.S. for Treatment

Ebola Patient Coming to U.S. for Treatment

Reuters - US Online Video (Aug. 1, 2014) A U.S. aid worker infected with Ebola while working in West Africa will be treated in a high security ward at Emory University in Atlanta. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins