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Passive smoking increases platelet activation in healthy people

Date:
August 25, 2012
Source:
European Society of Cardiology (ESC)
Summary:
It is well known that passive smoking is harmful for cardiovascular health, but the mechanism has not yet been discovered, researchers said. They investigated the effects of passive smoking on the levels of three parameters – mean platelet volume (MPV), carboxyhemoglobin (COHb) and lactate - in an effort to further understand this mechanism.

"It is well known that passive smoking is harmful for cardiovascular health, but the mechanism has not yet been discovered," said Dr Kaya. "We investigated the effects of passive smoking on the levels of three parameters -- mean platelet volume (MPV), carboxyhemoglobin (COHb) and lactate -- in an effort to further understand this mechanism. We also looked at the correlation between the three parameters."

Mean platelet volume (MPV) is a well established indicator of platelet activation that is increased in acute thrombotic events. It is suspected that carbon monoxide (CO) plays a major role in cigarette smoke-induced cardiovascular diseases. When CO binds with hemoglobin (Hb) in red blood cells it is called COHb. Lactate accumulates in the blood when the supply of oxygen to blood cells is limited.

For the study, 55 healthy nonsmoker volunteers (males 30%; mean age 265 years) were prospectively enrolled. Blood samples for measurements of MPV, COHb and lactate were taken at baseline and after spending one an hour in a smoking room.

The blood levels of all three parameters were statistically higher after subjects were exposed to passive smoking. COHb increased from 0.80.3% at baseline to 1.20.4% after one hour in a smoking room (p=0.001). Lactate increased from 0.700.2mmol/L to 2.20.9mmol/L (p=0.001). MPV increased from 7.80.4 femtolitres (fL) to 8.50.6fL (p= 0.001). Dr Kaya said: "These results show that passive smoking increases platelet activation and increases CO and lactate levels in the blood."

The researchers found significant correlations between MPV and COHb levels (r= 0.55, p=0.0001) and between MPV and lactate levels (r= 0.65, p=0.0001) after smoking. There was also a remarkable relation between COHb and lactate levels after smoking (r= 0.78, p=0.0001). Dr Kaya said: "Previous studies have suggested that the chemicals in cigarette smoke, especially nicotine and CO, increase platelet-activating factor. The correlations found in our study suggest that the CO in cigarette smoke also increases MPV levels. It is likely that lactate levels increased because oxygen levels in the blood dropped as CO increased."

He concluded: "We have shown that 1 hour exposure to passive smoking increases platelet activation, which could be the mechanism by which it contributes to increased risk of thrombotic events in healthy people. It is likely that prolonged exposure to passive smoking could have even greater effects. Healthy people should avoid exposure to passive smoking so that they do not increase their risk of thrombotic events."


Story Source:

The above story is based on materials provided by European Society of Cardiology (ESC). Note: Materials may be edited for content and length.


Cite This Page:

European Society of Cardiology (ESC). "Passive smoking increases platelet activation in healthy people." ScienceDaily. ScienceDaily, 25 August 2012. <www.sciencedaily.com/releases/2012/08/120825155656.htm>.
European Society of Cardiology (ESC). (2012, August 25). Passive smoking increases platelet activation in healthy people. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2012/08/120825155656.htm
European Society of Cardiology (ESC). "Passive smoking increases platelet activation in healthy people." ScienceDaily. www.sciencedaily.com/releases/2012/08/120825155656.htm (accessed April 16, 2014).

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