Featured Research

from universities, journals, and other organizations

Zebrafish study explains why the circadian rhythm affects your health

Date:
August 28, 2012
Source:
Linköping Universitet
Summary:
Disruptions to the circadian rhythm can affect the growth of blood vessels in the body, thus causing illnesses such as diabetes, obesity, and cancer, according to a new study.

A normal circadian rhythm regulates the genes needed to form the signalling substance VEGF, which in turn is necessary for blood vessel growth (angiogenesis). Light at night disturbs the circadian rhythm, and VEGF cannot be produced – blood vessel growth is inhibited, which can be seen in the microscope images at right.
Credit: Lasse Dahl Jensen

Disruptions to the circadian rhythm can affect the growth of blood vessels in the body, thus causing illnesses such as diabetes, obesity, and cancer, according to a new study from Linköping University and Karolinska Institutet in Sweden.

The circadian rhythm is regulated by a "clock" that reacts to both incoming light and genetic factors.

In an article now being published in the scientific journal Cell Reports, it is demonstrated for the first time that disruption of the circadian rhythm immediately inhibit blood vessel growth in zebra fish embryos.

Professor Yihai Cao leads a research group, which has demonstrated that the breaking point is the production of a very important signalling substance: vascular endothelial growth factor (VEGF). The formation of this substance requires a normal circadian rhythm.

During experiments with hours-old zebra fish embryos, the researchers manipulated their circadian rhythm through exposing them to lighting conditions varying from constant darkness to constant light. The growth of blood vessels in the various groups was then studied. The results showed that exposure to constant light (1800 lux) markedly impaired blood vessel growth; additionally, it affected the expression of genes that regulate the circadian clock.

"The results can definitely be translated into clinical circumstances. Individuals with disrupted circadian rhythms -- for example, shift workers who work under artificial lights at night, people with sleeping disorders or a genetic predisposition -- should be on guard against illnesses associated with disrupted blood vessel growth," says Lasse Dahl Jensen, researcher in Cardiovascular Physiology at Linköping University (LiU), and lead writer of the article.

Such diseases include heart attack, stroke, chronic inflammation, and cancer. Disruptions in blood vessel growth can also affect fetal development, women's reproductive cycles, and the healing of wounds.


Story Source:

The above story is based on materials provided by Linköping Universitet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lasse Dahl Jensen, Ziquan Cao, Masaki Nakamura, Yunlong Yang, Lars Bräutigam, Patrik Andersson, Yin Zhang, Eric Wahlberg, Toste Länne, Kayoko Hosaka, Yihai Cao. Opposing Effects of Circadian Clock Genes Bmal1 and Period2 in Regulation of VEGF-Dependent Angiogenesis in Developing Zebrafish. Cell Reports, 2012; DOI: 10.1016/j.celrep.2012.07.005

Cite This Page:

Linköping Universitet. "Zebrafish study explains why the circadian rhythm affects your health." ScienceDaily. ScienceDaily, 28 August 2012. <www.sciencedaily.com/releases/2012/08/120828073049.htm>.
Linköping Universitet. (2012, August 28). Zebrafish study explains why the circadian rhythm affects your health. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2012/08/120828073049.htm
Linköping Universitet. "Zebrafish study explains why the circadian rhythm affects your health." ScienceDaily. www.sciencedaily.com/releases/2012/08/120828073049.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) — Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) — At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) — Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins