Featured Research

from universities, journals, and other organizations

Unforeseen regulation of the anti-bacterial immune response discovered

Date:
August 28, 2012
Source:
Trudeau Institute
Summary:
New research holds promise for the improved prevention and treatment of bacterial infections and the life-threatening complications of chronic inflammation that can result from them.

New research from the laboratory of Dr. Andrea Cooper at the Trudeau Institute, just published in the European Journal of Immunology, holds promise for the improved prevention and treatment of bacterial infections and the life-threatening complications of chronic inflammation that can result from them.

Related Articles


Following a typical bacterial infection, the immune response is manifested by the accumulation of immune cells within the affected organs. In a bacterial skin infection, for example, this accumulation results in swelling and redness. When infection occurs in internal organs, a similar type of response takes place, but in this setting the immune response can actually damage the organs, resulting in their diminished function. Because of this risk, whenever the immune response acts to control bacteria, the response itself must also be regulated to prevent patient injury.

The publication defines the role of a specific component of the immune response in controlling the extent of the immune response. The authors show that cells that promote damaging inflammation are specifically regulated by the activated immune cells that are part of the inflammatory process. In this way, the immune response undergoes a negative feedback loop that regulates tissue damage but can also limit the expression of bacterial control.

Once bacteria enter the body, the disease process can occur in one of two ways: either the bacteria manipulates the immune regulatory pathways, limiting expression of an immune response (leading to too many bacteria and resulting in tissue damage), or the immune response is not well regulated, and the subsequent inflammatory response damages organs. Maintaining the balance between the killing of bacteria and regulation of the immune response is critical to the health of the patient. The better our understanding of how this balance is generated, the more easily the immune response can be manipulated to achieve an optimal outcome every time it is induced.


Story Source:

The above story is based on materials provided by Trudeau Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. John E. Pearl, Egidio Torrado, Michael Tighe, Jeffrey J. Fountain, Alejandra Solache, Tara Strutt, Susan Swain, Rui Appelberg, Andrea M Cooper. Nitric oxide inhibits the accumulation of CD4 CD44hiTbet CD69lo T cells in mycobacterial infection. European Journal of Immunology, 2012; DOI: 10.1002/eji.201142158

Cite This Page:

Trudeau Institute. "Unforeseen regulation of the anti-bacterial immune response discovered." ScienceDaily. ScienceDaily, 28 August 2012. <www.sciencedaily.com/releases/2012/08/120828135055.htm>.
Trudeau Institute. (2012, August 28). Unforeseen regulation of the anti-bacterial immune response discovered. ScienceDaily. Retrieved March 1, 2015 from www.sciencedaily.com/releases/2012/08/120828135055.htm
Trudeau Institute. "Unforeseen regulation of the anti-bacterial immune response discovered." ScienceDaily. www.sciencedaily.com/releases/2012/08/120828135055.htm (accessed March 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Reuters - Innovations Video Online (Feb. 27, 2015) A dongle that plugs into a Smartphone mimics a lab-based blood test for HIV and syphilis and can detect the diseases in 15 minutes, say researchers. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Doctor Says Head Transplants Possible Within Two Years

Doctor Says Head Transplants Possible Within Two Years

Buzz60 (Feb. 27, 2015) An Italian doctor is saying he could stick someone&apos;s head onto someone else&apos;s body. Patrick Jones (@Patrick_E_Jones) reports. Video provided by Buzz60
Powered by NewsLook.com
How Your Dentist Could Help Screen You For Diabetes

How Your Dentist Could Help Screen You For Diabetes

Newsy (Feb. 27, 2015) A new study from researchers at New York University suggests dentists could soon use blood samples taken from patients&apos; mouths to test for diabetes. Video provided by Newsy
Powered by NewsLook.com
The Best Tips to Makeover Your Health

The Best Tips to Makeover Your Health

Buzz60 (Feb. 27, 2015) If you&apos;re looking to boost your health this season, there are a few quick and easy steps to prompt you for success. Krystin Goodwin (@Krystingoodwin) has the best tips to give your health a makeover this spring! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins