Featured Research

from universities, journals, and other organizations

Study gives new insight on inflammation

Date:
August 30, 2012
Source:
Monash University
Summary:
Scientists' discovery of an important step in the body's process for healing wounds may lead to a new way of treating inflammation.

Red-fluorescing leukocytes migrating and lining up along a fresh wound edge at the tip of a zebra fish tail.
Credit: Image courtesy of Monash University

Scientists' discovery of an important step in the body's process for healing wounds may lead to a new way of treating inflammation.

A study published August 30 in Current Biology details how an international team of researchers led by Monash University's Australian Regenerative Medicine Institute (ARMI) discovered the mechanism, which shuts down the signal triggering the body's initial inflammatory response to injury.

When the body suffers a wound or abrasion, white blood cells, or leukocytes, travel to the site of the injury to protect the tissue from infection and start repairing the damage. However, this period of inflammation need only be temporary. If the body allows the inflammatory stage to continue for too long, the next phase of healing is compromised.

Previous research identified the initial signal that calls the leukocytes to the site of the injury, but how this early signal was switched off, letting the leukocytes know that they were no longer urgently needed, was unknown. The latest findings show that an enzyme called myeloperoxidase is the key to this process.

The team studied zebra fish with modified leukocytes and tissues that fluoresced different colours, enabling leukocyte movement and the concentration of chemical signals to be monitored simultaneously. By observing the tiny, transparent fish under a microscope, the researchers were able to observe individual white blood cells and how they are regulated in the inflammatory phase of the healing process.

Lead researcher Professor Graham Lieschke of ARMI said the findings suggested new possibilities for treating inflammation.

"White blood cell activity is important for determining the balance between repair, scarring and healing. Understanding what regulates leukocyte activity during inflammation should ultimately allow us to manipulate this system and maximise healing and repair," Professor Lieschke said.

"Our research has identified a new pathway to target with anti-inflammatory drugs. There is a significant need for new treatment options as current drugs are not effective in all circumstances."

Professor Lieschke said the findings were especially relevant to understanding and treating the hereditary disease myeloperoxidase deficiency, which affects leukocyte function in approximately one in every 2000 people.

The Monash University-led research was funded by the National Health and Medical Research Council of Australia and the National Institutes of Health in the USA. ARMI is supported by grants from the State Government of Victoria and the Australian Government.


Story Source:

The above story is based on materials provided by Monash University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Luke Pase, JudithE. Layton, Christine Wittmann, Felix Ellett, CameronJ. Nowell, ConstantinoCarlos Reyes-Aldasoro, Sony Varma, KellyL. Rogers, ChrisJ. Hall, M.Cristina Keightley, PhilipS. Crosier, Clemens Grabher, JoanK. Heath, StephenA. Renshaw, GrahamJ. Lieschke. Neutrophil-Delivered Myeloperoxidase Dampens the Hydrogen Peroxide Burst after Tissue Wounding in Zebrafish. Current Biology, 2012; DOI: 10.1016/j.cub.2012.07.060

Cite This Page:

Monash University. "Study gives new insight on inflammation." ScienceDaily. ScienceDaily, 30 August 2012. <www.sciencedaily.com/releases/2012/08/120830125958.htm>.
Monash University. (2012, August 30). Study gives new insight on inflammation. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2012/08/120830125958.htm
Monash University. "Study gives new insight on inflammation." ScienceDaily. www.sciencedaily.com/releases/2012/08/120830125958.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com
What's To Blame For Worst Ebola Outbreak In History?

What's To Blame For Worst Ebola Outbreak In History?

Newsy (July 27, 2014) A U.S. doctor has tested positive for the deadly Ebola virus, as the worst-ever outbreak continues to grow. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins