Featured Research

from universities, journals, and other organizations

Hundreds more bleeding trauma patients could be saved if tranexamic acid was used more widely, study suggests

Date:
September 12, 2012
Source:
BMJ-British Medical Journal
Summary:
The clot stabilizer drug tranexamic acid can be administered safely to a wide range of patients with traumatic bleeding and should not be restricted to the most severe cases, a new study suggests.

The clot stabilizer drug tranexamic acid can be administered safely to a wide range of patients with traumatic bleeding and should not be restricted to the most severe cases, a study published on bmj.com today suggests.

Previous studies have already shown that tranexamic acid significantly reduces death from all causes, without increasing the risk of thrombotic adverse events (formation of a blood clot in a blood vessel). As such, tranexamic acid is being incorporated into trauma protocols around the world, but these tend to focus on the most severely injured.

Researchers at the London School of Hygiene & Tropical Medicine therefore used data from a large randomised controlled trial to develop a prediction model to identify patients with life-threatening traumatic bleeding. They then used the model to see if the effects of the treatment vary according to the baseline risk of death. All patients were treated within three hours of injury.

Results show that in all risk groups there were fewer bleeding deaths among patients who had been treated with tranexamic acid. For all thrombotic events, 1.5% (98/6684) of patients treated with tranexamic acid died compared to 2.1% (140 / 6589) who did not receive tranexamic acid.

There was a significant reduction in the risk of unwanted clotting, in particular heart attacks, in those treated with tranexamic acid. The reduction in unwanted clotting again did not appear to vary by baseline risk. Because there are far more low and medium risk trauma patients than high risk patients, restricting use of tranexamic acid to high risk patients would mean that most of the benefits from using the drug are missed.

The authors conclude that tranexamic acid can be safely administered to a wide spectrum of bleeding trauma patients and its use should not be restricted to those with the most severe haemorrhage. To make sure that their life saving message reaches doctors the authors have prepared a short comic that presents the key facts in the context of a casualty drama. They suspect that some emergency physicians might prefer a short comic to a long research paper.

Link to cartoon: http://blogs.lshtm.ac.uk/news/2012/09/11/tranexamic-acid-manga-offers-comic-relief-for-medics/


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. I. Roberts, P. Perel, D. Prieto-Merino, H. Shakur, T. Coats, B. J. Hunt, F. Lecky, K. Brohi, K. Willett. Effect of tranexamic acid on mortality in patients with traumatic bleeding: prespecified analysis of data from randomised controlled trial. BMJ, 2012; 345 (sep11 1): e5839 DOI: 10.1136/bmj.e5839

Cite This Page:

BMJ-British Medical Journal. "Hundreds more bleeding trauma patients could be saved if tranexamic acid was used more widely, study suggests." ScienceDaily. ScienceDaily, 12 September 2012. <www.sciencedaily.com/releases/2012/09/120911200518.htm>.
BMJ-British Medical Journal. (2012, September 12). Hundreds more bleeding trauma patients could be saved if tranexamic acid was used more widely, study suggests. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2012/09/120911200518.htm
BMJ-British Medical Journal. "Hundreds more bleeding trauma patients could be saved if tranexamic acid was used more widely, study suggests." ScienceDaily. www.sciencedaily.com/releases/2012/09/120911200518.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

More Coverage


Comic Relief for Stressed Emergency Teams

Sep. 11, 2012 Researchers in the UK have created a comic influenced by the Japanese manga style to help busy medical staff who treat patients suffering from ... read more
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins