Featured Research

from universities, journals, and other organizations

A carefully scheduled high-fat diet resets metabolism and prevents obesity, researchers find

Date:
September 12, 2012
Source:
Hebrew University of Jerusalem
Summary:
New research shows that a carefully scheduled high-fat diet can lead to a reduction in body weight and a unique metabolism in which ingested fats are not stored, but rather used for energy at times when no food is available.

Prof. Oren Froy of the Hebrew University’s Robert H. Smith Faculty of Agriculture, Food and Environment.
Credit: Photo by Sasson Tiram

New research from the Hebrew University of Jerusalem shows that a carefully scheduled high-fat diet can lead to a reduction in body weight and a unique metabolism in which ingested fats are not stored, but rather used for energy at times when no food is available.

The research was conducted by Prof. Oren Froy along with Prof. Zecharia Madar, research student Yoni Genzer and research fellow Dr. Hadas Sherman at the Institute of Biochemistry, Food Science and Nutrition, at the Hebrew University's Robert H. Smith Faculty of Agriculture, Food and Environment. The results were published in The FASEB Journal under the title "Timed high-fat diet resets circadian metabolism and prevents obesity".

Previous research has established that disrupting mammals' daily rhythms, or feeding them a high-fat diet, disrupts metabolism and leads to obesity. The researchers wanted to determine the effect of combining a high-fat diet with long-term feeding on a fixed schedule. They hypothesized that careful scheduling of meals would regulate the biological clock and reduce the effects of a high-fat diet that, under normal circumstances, would lead to obesity.

For 18 weeks they fed a group of mice a high-fat diet on a fixed schedule (eating at the same time and for the same length of time every day). They compared these mice to three control groups: one that ate a low-fat diet on a fixed schedule, one that ate an unscheduled low-fat diet (in the quantity and frequency of its choosing), and one that ate an unscheduled high-fat diet.

All four groups of mice gained weight throughout the experiment, with a final body weight greater in the group that ate an unscheduled high-fat diet.

The mice on the scheduled high-fat diet had a lower final body weight than the mice eating an unscheduled high-fat diet. But surprisingly, the mice on the scheduled high-fat diet also had a lower final body weight than the mice that ate an unscheduled low-fat diet, even though both groups consumed the same amount of calories.

In addition, the mice on the scheduled high-fat diet exhibited a unique metabolic state in which the fats they ingested were not stored, but rather utilized for energy at times when no food was available, such as between meals.

According to Prof. Froy, "Our research shows that the timing of food consumption takes precedence over the amount of fat in the diet, leading to improved metabolism and helping to prevent obesity. Improving metabolism through the careful scheduling of meals, without limiting the content of the daily menu, could be used as a therapeutic tool to prevent obesity in humans."


Story Source:

The above story is based on materials provided by Hebrew University of Jerusalem. Note: Materials may be edited for content and length.


Journal Reference:

  1. H. Sherman, Y. Genzer, R. Cohen, N. Chapnik, Z. Madar, O. Froy. Timed high-fat diet resets circadian metabolism and prevents obesity. The FASEB Journal, 2012; 26 (8): 3493 DOI: 10.1096/fj.12-208868

Cite This Page:

Hebrew University of Jerusalem. "A carefully scheduled high-fat diet resets metabolism and prevents obesity, researchers find." ScienceDaily. ScienceDaily, 12 September 2012. <www.sciencedaily.com/releases/2012/09/120912084430.htm>.
Hebrew University of Jerusalem. (2012, September 12). A carefully scheduled high-fat diet resets metabolism and prevents obesity, researchers find. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2012/09/120912084430.htm
Hebrew University of Jerusalem. "A carefully scheduled high-fat diet resets metabolism and prevents obesity, researchers find." ScienceDaily. www.sciencedaily.com/releases/2012/09/120912084430.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins