Featured Research

from universities, journals, and other organizations

Children, young adults treated with radioactive iodine at elevated risk of developing secondary primary cancer

Date:
September 20, 2012
Source:
American Thyroid Association
Summary:
Children and young adult thyroid cancer patients who are treated with radioactive iodine have an elevated risk of developing a second primary malignancy, according to new data.

Children and young adult thyroid cancer patients who are treated with radioactive iodine have an elevated risk of developing a second primary malignancy, according to new data presented at the 82nd Annual Meeting of the American Thyroid Association in Québec City, Québec, Canada.

"The expected survival time for young patients with differentiated thyroid cancer is long. However, as new data elucidates, a need exists to judiciously weigh the benefits of radioactive iodine against the small, but real, increase in the risk of developing secondary primary malignancies," said Elizabeth Pearce, MD, of Boston Medical Center, and Program Co-Chair of the ATA Annual Meeting.

Though increasingly used as a treatment for differentiated thyroid cancer, long-term implication of radioactive iodine in children and young adults are not well defined. Existing data are limited to case series with limited follow-up that, in particular, may underestimate the risk of these patients developing secondary primary malignancies. To date, epidemiologic analyses of secondary primary malignancies risk have only been performed in the adult population.

A team of researchers led by Jennifer Marti, MD, of Beth Israel Medical Center in New York, thus sought to characterize of secondary primary malignancies among children. They analyzed 3,850 children and young adult patients (< 25 years old) with differentiated thyroid cancer who were followed in the NCI SEER cancer registry from 1973 to 2008. Among patients who were treated with radioactive iodine, researchers observed 26 cases of secondary primary malignancies, outnumbering the 18.3 cases researchers had expected. Researchers found that patients who were treated with radioactive iodine (40%) had a significantly elevated relative risk (SIR 1.42, p = .05) of developing a secondary primary malignancy at all sites; their risk of developing a salivary malignancy was especially elevated (SIR = 34.12, p < 0.001). Researchers also estimated that over a decade, ~1 in 227 children and young adults will develop a secondary primary malignancy attributed to radioactive iodine treatment and ~1 in 588 will develop a salivary cancer attributable to radioactive iodine treatment. Patients who were not treated with radioactive iodine did not have an elevated risk of developing a secondary primary malignancy.


Story Source:

The above story is based on materials provided by American Thyroid Association. Note: Materials may be edited for content and length.


Cite This Page:

American Thyroid Association. "Children, young adults treated with radioactive iodine at elevated risk of developing secondary primary cancer." ScienceDaily. ScienceDaily, 20 September 2012. <www.sciencedaily.com/releases/2012/09/120920153117.htm>.
American Thyroid Association. (2012, September 20). Children, young adults treated with radioactive iodine at elevated risk of developing secondary primary cancer. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2012/09/120920153117.htm
American Thyroid Association. "Children, young adults treated with radioactive iodine at elevated risk of developing secondary primary cancer." ScienceDaily. www.sciencedaily.com/releases/2012/09/120920153117.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) — The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) — Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) — Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins