Featured Research

from universities, journals, and other organizations

Patients with rheumatoid arthritis appear to be at increased risk for blood clots

Date:
October 2, 2012
Source:
American Medical Association (AMA)
Summary:
A study that included more than 45,000 residents of Sweden with rheumatoid arthritis finds that individuals with this disease had an associated higher risk of venous thromboembolism (a blood clot that forms within a vein), and that this elevated risk was stable for 10 years after the time of diagnosis.

A study that included more than 45,000 residents of Sweden with rheumatoid arthritis finds that individuals with this disease had an associated higher risk of venous thromboembolism (a blood clot that forms within a vein), and that this elevated risk was stable for 10 years after the time of diagnosis, according to a study in the October 3 issue of JAMA.

"Recent reports suggest that rheumatoid arthritis (RA) may be a risk factor for venous thromboembolism (VTE), particularly in conjunction with hospitalization. Using hospitalization data to identify RA and VTE may identify patients when they are at elevated risk for other reasons, obscuring the incompletely understood underlying association between RA and VTE and leading to inappropriate institution or timing of interventions," according to background information in the article.

Marie E. Holmqvist, M.D., Ph.D., of the Karolinska Institutet, Stockholm, Sweden and colleagues conducted a study to assess the overall occurrence and relative risks of VTE in patients with RA in relation to RA onset and disease duration as well as in conjunction with hospitalization. The study included a prevalent RA group (n = 37,856), an incident RA group (n = 7,904), and matched general population comparison groups, all from Sweden, with follow-up from 1997 through 2010.

Of the patients with prevalent RA and the matched individuals in the general population comparison cohort, 838 patients (2.2 percent) and 1,866 matched individuals (1.1 percent) had a VTE event after the index date, with analysis of the data indicating that patients with prevalent RA were at greater risk of VTE than the general population. There was no statistically significant association between a history of VTE and RA by the time of RA symptom onset. Counting from RA diagnosis, an increased rate in the RA cohort vs. the comparison cohort was detected within the first year and did not increase further during the first decade. The researchers also found that although rates for VTE following hospitalization were higher, the 1-year rate of VTE was not higher in the RA cohort than in the comparison cohort after hospital discharge. The rates of VTE increased with age but were largely similar across sex and rheumatoid factor status.

"The results of this study suggest that patients with RA are at increased risk of VTE (both deep vein thrombosis and pulmonary embolism) and that the risk of VTE increases shortly after RA diagnosis and remains similarly elevated during the first decade," the authors write.

"Hospitalization is a strong risk factor for VTE in the general population and in patients with RA, but the short-term (<1 year after hospital discharge) rates for VTE are similar in both groups. VTE rates varied with age, less so with sex, calendar period of RA diagnosis, and rheumatoid factor status, but the relative risks of VTE were largely similar across these patient subgroups."


Story Source:

The above story is based on materials provided by American Medical Association (AMA). Note: Materials may be edited for content and length.


Journal Reference:

  1. Marie E. Holmqvist et al. Risk of Venous Thromboembolism in Patients With Rheumatoid Arthritis and Association With Disease Duration and HospitalizationVenous Thromboembolism in Rheumatoid Arthritis. JAMA: The Journal of the American Medical Association, 2012; 308 (13): 1350 DOI: 10.1001/2012.jama.11741

Cite This Page:

American Medical Association (AMA). "Patients with rheumatoid arthritis appear to be at increased risk for blood clots." ScienceDaily. ScienceDaily, 2 October 2012. <www.sciencedaily.com/releases/2012/10/121002161755.htm>.
American Medical Association (AMA). (2012, October 2). Patients with rheumatoid arthritis appear to be at increased risk for blood clots. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2012/10/121002161755.htm
American Medical Association (AMA). "Patients with rheumatoid arthritis appear to be at increased risk for blood clots." ScienceDaily. www.sciencedaily.com/releases/2012/10/121002161755.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins