Featured Research

from universities, journals, and other organizations

Mice with Lou Gehrig's disease not quite what the doctors ordered

Date:
October 5, 2012
Source:
Alzheimer Research Forum Foundation
Summary:
You’ve heard the tale before: Scientists can treat diseases like Alzheimer’s and Lou Gehrig’s in mice, but when those same drugs get to human trials, they fail. Can researchers come up with mice that better mimic the patient? In the case of Lou Gehrig’s, some of the latest mice have a problem: they die not because of their spinal nerve disease, but due to blockage of their gut.

The mice in which scientists expected to test treatments for Lou Gehrig's disease turn out to have problems that could slow research, reported Alzforum, a research news site specializing in Alzheimer's and related diseases. To the researchers' surprise, the mice didn't die of the spinal nerve disease. Instead, they succumbed to intestinal blockage.

"There were high expectations," said Robert Baloh of the Cedars-Sinai Medical Center in Los Angeles, who made the new mice. "The problem is, they are still mice. Humans and mice, even if they have the same genetic mutation, get different diseases."

Between 20,000 and 30,000 people in the U.S. have Lou Gehrig's disease, or amyotrophic lateral sclerosis, which kills nerve cells in the spine. It causes paralysis and death, typically within a few years. There is only one treatment, riluzole, which extends live by a couple of months.

Difficulties in transferring treatments from mice to people have long plagued scientists trying to treat Lou Gehrig's and Alzheimer's. That's why researchers were excited when, five years ago, it was discovered that some people with Lou Gehrig's have mutations in a gene called TDP-43. They rushed to make mice with the same mutations, thinking the animals would be an excellent new testing ground.

But problems, such as the intestinal blockage, are arising as scientists work to fully understand the new mice. Nonetheless, the mice could still be useful in testing drugs and should also help researchers understand just how Lou Gehrig's kills nerve cells, experts say. And in the process, scientists are learning just how rigorously they have to characterize a given mouse model, and design treatment studies in those mice, to then have a fair shot at success in the clinic.


Story Source:

The above story is based on materials provided by Alzheimer Research Forum Foundation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jada Lewis et al. Are TDP-43 Mice Living Up to Expectations? Alzforum, September 20, 2012 [link]

Cite This Page:

Alzheimer Research Forum Foundation. "Mice with Lou Gehrig's disease not quite what the doctors ordered." ScienceDaily. ScienceDaily, 5 October 2012. <www.sciencedaily.com/releases/2012/10/121005134621.htm>.
Alzheimer Research Forum Foundation. (2012, October 5). Mice with Lou Gehrig's disease not quite what the doctors ordered. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2012/10/121005134621.htm
Alzheimer Research Forum Foundation. "Mice with Lou Gehrig's disease not quite what the doctors ordered." ScienceDaily. www.sciencedaily.com/releases/2012/10/121005134621.htm (accessed July 29, 2014).

Share This




More Plants & Animals News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rodents Rampant in Gardens Around Louvre

Rodents Rampant in Gardens Around Louvre

AP (July 29, 2014) Food scraps and other items left on the grounds by picnickers brings unwelcome visitors to the grounds of the world famous and popular Louvre Museum in Paris. (July 29) Video provided by AP
Powered by NewsLook.com
Jane Goodall Warns Great Apes Face Extinction

Jane Goodall Warns Great Apes Face Extinction

AFP (July 29, 2014) The world's great apes face extinction within decades, renowned chimpanzee expert Jane Goodall warned Tuesday in a call to arms to ensure man's closest relatives are not wiped out. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
How Your Face Can Leave A Good Or Bad First Impression

How Your Face Can Leave A Good Or Bad First Impression

Newsy (July 29, 2014) Researchers have found certain facial features can make us seem more attractive or trustworthy. Video provided by Newsy
Powered by NewsLook.com
Rat Infestation at Paris' Tuileries Garden

Rat Infestation at Paris' Tuileries Garden

AFP (July 29, 2014) An infestation of rats is causing concern among tourists at Paris' most famous park -- the Tuileries garden next to the Louvre Museum. Duration: 00:54 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins