Featured Research

from universities, journals, and other organizations

U.S. nationwide meningitis outbreak update

Date:
October 7, 2012
Source:
Centers for Disease Control and Prevention
Summary:
In response to a nationwide outbreak of meningitis and stroke associated with a widely distributed medication, CDC is providing updated guidance to clinicians and patients about contaminated medication products received from the New England Compounding Center located in Framingham, Mass. Patients have suffered a variety of symptoms, including those associated with a rare form of fungal meningitis (brain infection) and stroke.

In response to a nationwide outbreak of meningitis and stroke associated with a widely distributed medication, CDC is providing updated guidance to clinicians and patients about contaminated medication products received from the New England Compounding Center located in Framingham, Mass. Patients have suffered a variety of symptoms, including those associated with a rare form of fungal meningitis (brain infection) and stroke.

Related Articles


On October 3, 2012, the pharmaceutical compounding center ceased all production and initiated recall of all methylprednisolone acetate (a steroid medication) and other drug products prepared for injections in and around the spinal cord (known as intrathecal administration). In addition, CDC and state health departments have released the names of approximately 75 healthcare facilities in 23 states that have received contaminated product.

As of October 5, a total of 47 cases* in 7 states and 5 deaths have been identified with a clinical picture consistent with fungal infection: Florida (2 cases), Indiana (3 cases), Maryland (2 cases, including 1 death), Michigan (4 cases), North Carolina (1 case), Tennessee (29 cases, including 3 deaths), and Virginia (6 cases, including 1 death). Fungus has been identified in specimens obtained from 9 patients, including Aspergillus and Exserohilum.

"All patients who may have received these medications need to be tracked down immediately. Patients can find the names of the clinics that used these medications on the CDC website," said Benjamin Park, M.D., medical officer, Mycotic Diseases Branch, CDC. "It is possible that if patients with infection are identified soon and put on appropriate antifungal therapy, lives may be saved."

Infected patients have developed a variety of symptoms approximately 1 to 4 weeks following their injection, including fever, new or worsening headache, nausea, and new neurological deficit (consistent with deep brain stroke). Some of these patients' symptoms were very mild in nature. Cerebrospinal fluid obtained from these patients has shown findings consistent with meningitis.

On September 26, 2012, the New England Compounding Center voluntarily recalled the following lots of methylprednisolone acetate (PF) 80mg/ml:

  • Methylprednisolone Acetate (PF) 80 mg/ml Injection, Lot #05212012@68, BUD 11/17/2012
  • Methylprednisolone Acetate (PF) 80 mg/ml Injection, Lot #06292012@26, BUD 12/26/2012
  • Methylprednisolone Acetate (PF) 80 mg/ml Injection, Lot #08102012@51, BUD 2/6/2013

Physicians should immediately contact patients who have had an injection (e.g., spinal, joint) using any of the three lots of methylprednisolone acetate listed above to determine if they are having any symptoms. Although all cases detected to date occurred after injections with products from these three lots, out of an abundance of caution, CDC and the Food and Drug Administration (FDA) recommend that healthcare professionals cease use of any product produced by the New England Compounding Center until further information is available.

Patients who have had an epidural steroid injection since May 21, 2012, and have any of the following symptoms, should talk to their doctor as soon as possible.

  • Worsening headache
  • Fever
  • Sensitivity to light
  • Stiff neck
  • New weakness or numbness in any part of your body
  • Slurred speech

CDC has activated its Emergency Operations Center in an effort to maximize its response capabilities and to ensure that CDC recommendations are distributed as broadly as possible. CDC has provided guidance to clinicians on diagnostic testing that should be performed on patient specimens: http://www.cdc.gov/hai/pdfs/outbreaks/Outbreak-diagnostic-protocol-cleared.pdf

Clinicians should inform their State health department of any patients undergoing evaluation for this infection. Clinicians should report any suspected adverse events following use of these products to FDA's MedWatch program at 1-800-332-1088 or www.fda.gov/medwatch.

The 23 states where the contaminated product was shipped are California, Connecticut, Florida, Georgia, Idaho, Illinois, Indiana, Maryland, Michigan, Minnesota, North Carolina, New Hampshire, New Jersey, Nevada, New York, Ohio, Pennsylvania, Rhode Island, South Carolina, Tennessee, Virginia, Texas, and West Virginia. For a list of all of the facilities who have received contaminated product, please see: http://www.cdc.gov/hai/outbreaks/meningitis-facilities-map.html

*CDC Case Definition

  1. A person with meningitis1 of sub-acute onset (1-4 weeks) following epidural injection after May 21, 2012.
  2. A person, who has not received a lumbar puncture, with basilar stroke 1-4 weeks following epidural injection after May 21, 20122.
  3. A person with evidence of spinal osteomyelitis or epidural abscess at the site of an epidural injection diagnosed 1-4 weeks after epidural injection after May 21, 2012. 1clinically diagnosed meningitis meaning 1 or more of the following symptoms: headache, fever, stiff neck, or photophobia and a cerebrospinal fluid profile consistent with meningitis (elevated protein/low glucose/pleocytosis) 2These people, if possible, should have a lumbar puncture.

Story Source:

The above story is based on materials provided by Centers for Disease Control and Prevention. Note: Materials may be edited for content and length.


Cite This Page:

Centers for Disease Control and Prevention. "U.S. nationwide meningitis outbreak update." ScienceDaily. ScienceDaily, 7 October 2012. <www.sciencedaily.com/releases/2012/10/121007190851.htm>.
Centers for Disease Control and Prevention. (2012, October 7). U.S. nationwide meningitis outbreak update. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2012/10/121007190851.htm
Centers for Disease Control and Prevention. "U.S. nationwide meningitis outbreak update." ScienceDaily. www.sciencedaily.com/releases/2012/10/121007190851.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins