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Fresh blood not better for transfusions for premature infants, clinical trial shows

Date:
October 8, 2012
Source:
Ottawa Hospital Research Institute
Summary:
In a finding that runs counter to commonly held beliefs about fresh being better, a clinical trial shows that acutely ill premature babies who received fresher blood did not fare better than those who received the current standard of care. There was no difference between the two approaches with respect to major organ injury, mortality and infection.

In a finding that runs counter to commonly held beliefs about fresh being better, a clinical trial published October 8 by the Journal of the American Medical Association shows that acutely ill premature babies who received fresher blood did not fare better than those who received the current standard of care. There was no difference between the two approaches with respect to major organ injury, mortality and infection.

"Before now, most of the literature on the subject suggested that fresh red blood cells are better," says lead author Dr. Dean Fergusson, who heads up the Clinical Epidemiology Program at the Ottawa Hospital Research Institute and is an associate professor at the University of Ottawa. "However, the effect of fresher blood on clinical outcomes had never been examined using a randomized clinical trial in human patients, which is considered the gold standard in medical science. Now it has, and we found the standards currently in place are no different for this highly vulnerable population of pre-term infants than a policy and system that would favour fresh blood."

Previous observational studies of patient outcomes used already existing clinical data, which is problematic for a number of key reasons. Determining the average age of blood and its impact for those transfused more than once is very difficult because the age of red blood cells used in each transfusion could range dramatically within the acceptable shelf life of 42 days.

Called the ARIPI Randomized Trial, which stands for Age of Red Blood Cells in Premature Infants, this study involved 377 babies weighing less than 1,250 grams and requiring red blood cell transfusions. Randomly, they either received blood that had been stored a week or less, or received the current standard of practice used by blood banks. It turned out that there was no difference in outcome between the two groups.

"Over the years, the number of retrospective studies showing possible harm from older blood has created pressure to change the management of the blood supply to provide fresher transfusion products," says Dr. Dana Devine, Vice President, Medical, Scientific & Research Affairs of Canadian Blood Services. "This is a huge undertaking that would require many more donations than we currently have and greatly increase the cost of operating the blood system.

"To have this particular human clinical trial saying otherwise is important because it is the first such study using the highest level of evidence, the randomized controlled trial, and it was done in a very vulnerable patient population."

The findings of this trial, which took place between May 2006 and June 2011, could not have happened without the hundreds of parents who consented to enroll their children in the study.

"For the families, it's a difficult decision at a difficult time to allow their tiny and fragile child to be a part of a clinical trial. On behalf of the entire team involved in this trial, I salute and thank the families for allowing us to make this important finding," says Dr. Nicole Rouvinez-Bouali, an academic neonatologist at the Children's Hospital of Eastern Ontario.

The ARIPI trial included six Canadian hospitals: The Ottawa Hospital, Children's Hospital of Eastern Ontario (Ottawa), Jewish General Hospital (Montreal), Royal University Hospital (Saskatoon), Children's and Women's Health Centre of British Columbia (Vancouver), and CHU Sainte-Justine (Montreal).

Funding for the ARIPI Randomized Trial was provided by the Canadian Institutes of Health Research.


Story Source:

The above story is based on materials provided by Ottawa Hospital Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Dean A. Fergusson et al. Effects of Fresh Red Blood Cell Transfusions on Clinical Outcomes in Premature, Very Low-Birth-Weight Infants. JAMA, 2012 DOI: 10.1001/2012.jama.11953

Cite This Page:

Ottawa Hospital Research Institute. "Fresh blood not better for transfusions for premature infants, clinical trial shows." ScienceDaily. ScienceDaily, 8 October 2012. <www.sciencedaily.com/releases/2012/10/121008091653.htm>.
Ottawa Hospital Research Institute. (2012, October 8). Fresh blood not better for transfusions for premature infants, clinical trial shows. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2012/10/121008091653.htm
Ottawa Hospital Research Institute. "Fresh blood not better for transfusions for premature infants, clinical trial shows." ScienceDaily. www.sciencedaily.com/releases/2012/10/121008091653.htm (accessed April 17, 2014).

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