Featured Research

from universities, journals, and other organizations

New MRI technique used to identify early-stage coronary disease

Date:
October 9, 2012
Source:
Radiological Society of North America
Summary:
With the results of an MRI study from the National Institutes of Health, researchers say they are closer to finding an imaging technique that can identify thickening of the coronary artery wall, an early stage of coronary heart disease.

With the results of a magnetic resonance imaging (MRI) study from the National Institutes of Health (NIH), researchers say they are closer to finding an imaging technique that can identify thickening of the coronary artery wall, an early stage of coronary heart disease (CAD). The study is published online in the journal Radiology.

"Imaging the coronary arteries that supply the heart with blood is extremely difficult because they are very small and constantly in motion," said lead researcher Khaled Z. Abd-Elmoniem, Ph.D., staff scientist in the Biomedical and Metabolic Imaging branch of NIH's National Institute of Diabetes and Digestive and Kidney Diseases. "Obtaining a reliable and accurate image of these vessels is very important because thickening of the vessel wall is an early indicator of atherosclerosis."

CAD occurs when deposits of fat and cholesterol called plaques build up inside coronary arteries (a condition called atherosclerosis), increasing the risk of a heart attack and other coronary events. By identifying the vessel wall thickening that precedes artery narrowing, early intervention is possible.

"We currently have no reliable way to noninvasively image coronary artery disease in its early stages, when the disease can be treated with lifestyle changes and medications to lower cholesterol," Dr. Abd-Elmoniem said.

The researchers used MRI to measure the wall thickness of the coronary arteries in 26 patients with at least one risk factor for CAD and 12 healthy control participants matched to patients by body mass index (BMI). The mean age of the patients, which included 13 men and 13 women, was 48; healthy controls included three men and nine women (mean age 26).

To measure the coronary artery wall thickness in each of the study's participants, the researchers used both a single-frame MRI scan and an MRI technique called time-resolved multi-frame acquisition, in which five continuous images are captured in order to increase the success rate of obtaining an image free of blurring.

Using the time-resolved multi-frame acquisition method, the success rate for obtaining a usable image was 90 percent versus a success rate of 76 percent for the single-frame method.

Use of the time-resolved multi-frame technique also resulted in a greater ability to detect a significant difference between the wall thickness measurements of CAD patients and the healthy participants, as well as a smaller standard deviation, which is indicative of more precise measurements.

"These results suggest that MRI may be used in the future to screen for individuals at risk for coronary artery disease and may be useful for monitoring the effects of therapies," Dr. Abd-Elmoniem said.

"Dr. Abd-Elmoniem is a bright and inventive scientist who first suggested this innovative approach to improving coronary wall imaging," said Roderic Pettigrew, Ph.D., M.D., Director of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) and senior collaborator of the study. "We are delighted that the technique is showing such practical promise."

Dr. Abd-Elmoniem said that unlike blood tests that measure cholesterol and lipids in the blood, which can be indicators of atherosclerosis, the thickness of coronary artery walls is a direct measurement of early-stage CAD. He said additional studies are needed to validate the time-resolved multi-frame MRI technique.


Story Source:

The above story is based on materials provided by Radiological Society of North America. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ahmed M. Gharib, and Roderic I. Pettigrew. Coronary Vessel Wall 3-T MR Imaging with Time-resolved Acquisition of Phase-Sensitive Dual Inversion-Recovery (TRAPD) Technique: Initial Results in Patients with Risk Factors for Coronary Artery Disease. Radiology, 2012; DOI: 10.1148/radiol.12120068

Cite This Page:

Radiological Society of North America. "New MRI technique used to identify early-stage coronary disease." ScienceDaily. ScienceDaily, 9 October 2012. <www.sciencedaily.com/releases/2012/10/121009093023.htm>.
Radiological Society of North America. (2012, October 9). New MRI technique used to identify early-stage coronary disease. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2012/10/121009093023.htm
Radiological Society of North America. "New MRI technique used to identify early-stage coronary disease." ScienceDaily. www.sciencedaily.com/releases/2012/10/121009093023.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins