Featured Research

from universities, journals, and other organizations

Satiation hormone could increase risk of diabetes, heart attack and breast cancer in women

Date:
October 10, 2012
Source:
Lund University
Summary:
One of the body's satiation hormones, neurotensin, could raise women's risk of suffering one of three common and serious conditions: diabetes, cardiovascular disease and breast cancer. There is also a connection between the hormone and premature death in women, especially from cardiovascular disease.

One of the body's satiation hormones, neurotensin, could raise women's risk of suffering one of three common and serious conditions: diabetes, cardiovascular disease and breast cancer. There is also a connection between the hormone and premature death in women, especially from cardiovascular disease.

The findings have been presented in a study from Lund University in Sweden, published in the Journal of the American Medical Association.

"It was surprising to find such a clear link to the risk of type 2 diabetes and cardiovascular disease as well as to breast cancer. Obesity is a common risk factor for all three conditions, but the connection with neurotensin is not explained by obesity or other known risk factors," says Professor Olle Melander from the Department of Clinical Sciences at Lund University, who is also a consultant at Skεne University Hospital.

"This is the first time a satiation hormone has been linked to these three common diseases in women. It therefore opens up a new field for continued research on risk assessment and preventive treatment," says Professor Marju Orho-Melander from the Department of Clinical Sciences at Lund University, one of the authors of the study.

It is interesting that the findings apply specifically to women. In the case of breast cancer this is obvious, but a better understanding of the development of cardiovascular disease in women is greatly needed.

The connection between neurotensin and these conditions in women was seen to be so strong that it has a clear impact on the patient's life expectancy. The strong connection also means it is appropriate to use neurotensin as a clinical risk marker for the conditions, in the view of the researchers. This provides new opportunities for early identification of women who are likely to develop cardiovascular disease, which cannot be predicted with the current known risk factors. This makes it possible to initiate preventive treatment at an early stage.

"Because the hormone circulates around the body in the blood, levels can be measured with a normal blood test, which is an advantage," explains Olle Melander.

The results were obtained through analysis of blood samples from over 4 600 people who took part in the Swedish population study Malmφ Diet and Cancer. The participants gave blood samples over several years and the researchers saw a link between the level of neurotensin and the women who went on to develop one of the three diseases.

A low-fat diet reduces neurotensin production and could therefore be one way to regulate neurotensin levels, believe Olle Melander and Marju Orho-Melander. However, they point out that if neurotensin is to work as a target for treatment, a causal relationship must first be established. They hope to be able to identify this relationship through genetic studies that are currently underway.


Story Source:

The above story is based on materials provided by Lund University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Melander O, Maisel AS, Almgren P, et al. Plasma Proneurotensin and Incidence of Diabetes, Cardiovascular Disease, Breast Cancer, and Mortality. JAMA, 2012; 308 (14): 1469-1475 DOI: 10.1001/jama.2012.12998

Cite This Page:

Lund University. "Satiation hormone could increase risk of diabetes, heart attack and breast cancer in women." ScienceDaily. ScienceDaily, 10 October 2012. <www.sciencedaily.com/releases/2012/10/121010092816.htm>.
Lund University. (2012, October 10). Satiation hormone could increase risk of diabetes, heart attack and breast cancer in women. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2012/10/121010092816.htm
Lund University. "Satiation hormone could increase risk of diabetes, heart attack and breast cancer in women." ScienceDaily. www.sciencedaily.com/releases/2012/10/121010092816.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) — The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) — Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) — Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:  

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile iPhone Android Web
    Follow Facebook Twitter Google+
    Subscribe RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins