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Squeezing ovarian cancer cells to predict metastatic potential: Cell stiffness as possible biomarker

Date:
October 10, 2012
Source:
Georgia Institute of Technology
Summary:
New research shows that cell stiffness could be a valuable clue for doctors as they search for and treat cancerous cells before they're able to spread. The findings found that highly metastatic ovarian cancer cells are several times softer than less metastatic ovarian cancer cells.

Squeezing cancer cells. An AFM, holding a microscale cantilever, is positioned just above a petri dish filled with ovarian cancer cells.
Credit: Image courtesy of Georgia Institute of Technology

New Georgia Tech research shows that cell stiffness could be a valuable clue for doctors as they search for and treat cancerous cells before they're able to spread. The findings, which are published in the journal PLoS One, found that highly metastatic ovarian cancer cells are several times softer than less metastatic ovarian cancer cells.

Assistant Professor Todd Sulchek and Ph.D. student Wenwei Xu used a process called atomic force microscopy (AFM) to study the mechanical properties of various ovarian cell lines. A soft mechanical probe "tapped" healthy, malignant and metastatic ovarian cells to measure their stiffness.

"In order to spread, metastatic cells must push themselves into the bloodstream. As a result, they must be highly deformable and softer," said Sulchek, a faculty member in the George W. Woodruff School of Mechanical Engineering. "Our results indicate that cell stiffness may be a useful biomarker to evaluate the relative metastatic potential of ovarian and perhaps other types of cancer cells."

Just as previous studies on other types of epithelial cancers have indicated, Sulchek also found that cancerous ovarian cells are generally softer and display lower intrinsic variability in cell stiffnesss than non-malignant cells.

Sulchek's lab partnered with the molecular cancer lab of Biology Professor John McDonald, who is also director of Georgia Tech's newly established Integrated Cancer Research Center.

"This is a good example of the kinds of discoveries that only come about by integrating skills and knowledge from traditionally diverse fields such as molecular biology and bioengineering," said McDonald. "Although there are a number of developing methodologies to identify circulating cancer cells in the blood and other body fluids, this technology offers the added potential to rapidly determine if these cells are highly metastatic or relatively benign."

Sulchek and McDonald believe that, when further developed, this technology could offer a huge advantage to clinicians in the design of optimal chemotherapies, not only for ovarian cancer patients but also for patients of other types of cancer.


Story Source:

The above story is based on materials provided by Georgia Institute of Technology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Wenwei Xu, Roman Mezencev, Byungkyu Kim, Lijuan Wang, John McDonald, Todd Sulchek. Cell Stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells. PLoS ONE, 2012; 7 (10): e46609 DOI: 10.1371/journal.pone.0046609

Cite This Page:

Georgia Institute of Technology. "Squeezing ovarian cancer cells to predict metastatic potential: Cell stiffness as possible biomarker." ScienceDaily. ScienceDaily, 10 October 2012. <www.sciencedaily.com/releases/2012/10/121010131556.htm>.
Georgia Institute of Technology. (2012, October 10). Squeezing ovarian cancer cells to predict metastatic potential: Cell stiffness as possible biomarker. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2012/10/121010131556.htm
Georgia Institute of Technology. "Squeezing ovarian cancer cells to predict metastatic potential: Cell stiffness as possible biomarker." ScienceDaily. www.sciencedaily.com/releases/2012/10/121010131556.htm (accessed September 20, 2014).

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