Featured Research

from universities, journals, and other organizations

Lives could be saved by removing age restrictions on rotavirus vaccination, study suggests

Date:
October 23, 2012
Source:
Public Library of Science
Summary:
A new study, which suggests that the additional children's lives saved by removing the age restrictions for rotavirus vaccination in low- and middle-income countries would be much greater than any extra deaths from vaccine-associated complications (namely, intussusception-a form of bowel obstruction), has informed policy regarding the age restrictions for this vaccine.

A study published in this week's PLOS Medicine, which suggests that the additional children's lives saved by removing the age restrictions for rotavirus vaccination in low- and middle-income countries would be much greater than any extra deaths from vaccine-associated complications (namely, intussusception-a form of bowel obstruction), has informed policy regarding the age restrictions for this vaccine.

Hundreds of thousands of infants world-wide have been vaccinated against rotavirus (which causes vomiting and diarrhea and can kill young children) but this vaccine can slightly increase the risk of intussusception, with some countries reporting a risk of 1-4 additional cases per 100,000 vaccinated infants. As older infants have a higher risk of naturally occurring intussusception, the World Health Organization previously decided that the course of rotavirus vaccination should be initiated before the age of 15 weeks and completed before the age of 32 weeks. In poorer countries, where access to health facilities is more difficult, this age restriction could exclude many eligible infants from being vaccinated against rotavirus because of delays in the vaccination program.

In a modelling study, the authors from the Centers for Disease Control and Prevention and the London School of Hygiene and Tropical Medicine analysed the benefits and risks of rotavirus vaccination if the age restrictions were removed, and the rotavirus vaccine given to children alongside other routine childhood immunizations.

Using their model, the authors found that that in low-and low-middle income countries, keeping the age restrictions would prevent 155,800 rotavirus deaths, while potentially causing 253 deaths from intussusception. However, lifting the age restrictions would prevent 203,000 rotavirus deaths while potentially causing 547 intussusception deaths. Overall, the authors found that lifting the age restriction would result in an additional 47,200 deaths from rotavirus prevented versus 294 intussusception deaths caused, translating to 154 deaths prevented for every death caused by complications of the vaccine.

Experts from the World Health Organization reviewed the results from this study and while still encouraging timely vaccination, the World Health Organization no longer universally recommends age restrictions and supports removing age restrictions in settings where the benefits outweigh the risks.

The authors say: "Our analysis suggests that in low- and middle-income countries the additional lives saved by removing age restrictions for rotavirus vaccination would far outnumber the potential excess vaccine-associated intussusception deaths."

The authors continue: "Age restriction policies will ultimately be decided at country level, but this analysis has shown a clear case for a change in policy that will be particularly instrumental for saving lives in settings where mortality from rotavirus is high and delays in timing of vaccination are common."


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Manish M. Patel, Andrew D. Clark, Colin F. B. Sanderson, Jacqueline Tate, Umesh D. Parashar. Removing the Age Restrictions for Rotavirus Vaccination: A Benefit-Risk Modeling Analysis. PLoS Medicine, 2012; 9 (10): e1001330 DOI: 10.1371/journal.pmed.1001330

Cite This Page:

Public Library of Science. "Lives could be saved by removing age restrictions on rotavirus vaccination, study suggests." ScienceDaily. ScienceDaily, 23 October 2012. <www.sciencedaily.com/releases/2012/10/121023172115.htm>.
Public Library of Science. (2012, October 23). Lives could be saved by removing age restrictions on rotavirus vaccination, study suggests. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2012/10/121023172115.htm
Public Library of Science. "Lives could be saved by removing age restrictions on rotavirus vaccination, study suggests." ScienceDaily. www.sciencedaily.com/releases/2012/10/121023172115.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins