Featured Research

from universities, journals, and other organizations

Prasugrel may reduce cardiovascular events among patients managed medically after an angiogram for acute coronary syndrome

Date:
October 24, 2012
Source:
Cardiovascular Research Foundation
Summary:
A study has found that the anti-clotting medication prasugrel reduced cardiovascular events among patients who present with an acute coronary syndrome and are managed medically after an angiogram is performed to determine coronary anatomy. Results of the TRILOGY ACS trial, Angiographic Cohort were presented today at the 24th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation, TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine.

A study has found that the anti-clotting medication prasugrel reduced cardiovascular events among patients who present with an acute coronary syndrome and are managed medically after an angiogram is performed to determine coronary anatomy. Results of the TRILOGY ACS trial, Angiographic Cohort were presented October 24 at the 24th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium.

Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 platelet inhibitor is beneficial in patients with unstable angina (UA) or non-ST segment elevation myocardial infarction (NSTEMI). Because a substantial fraction of these patients do not undergo revascularization after angiography, their optimal DAPT strategy is unknown.

The TRILOGY ACS trial compared prasugrel with aspirin versus clopidogrel with aspirin in the primary cohort of 7,243 UA/NSTEMI patients less than 75 years old who were medically managed without revascularization and had at least one high-risk criterion. The primary results of this study, presented at the European Society of Cardiology earlier this year, did not show any benefit for prasugrel with aspirin versus clopidogrel.

Patients were enrolled in 52 countries from June 2008 through September 2011 with median follow-up of 17 months. Those who weighed more than 60 kg were treated with a 10 mg maintenance dose of prasugrel versus 75 mg of clopidogrel; patients less than 60 kg received 5 mg of prasugrel.

Angiography was not required for enrollment, but if performed, evidence of coronary disease had to be demonstrated (at least one lesion > 30 percent stenosis or prior percutaneous coronary intervention/ coronary artery bypass graft surgery). Approximately 43% of the patients had angiography performed and coronary anatomy determined before being triaged to medical therapy.

Overall, in the TRILOGY ACS Trial, prasugrel did not reduce cardiovascular events among patients managed medically for ACS.

However, when treated with prasugrel compared to clopidogrel, patients who were triaged to medical therapy in the trial following angiography tended to have:

  • Lower rates of the combined endpoint of cardiovascular disease/heart attack/stroke
  • Lower rates of heart attack, stroke alone, and recurrent ischemic events
  • Higher rates of bleeding

"Though hypothesis-generating, these results are consistent with previous trials and suggest that when angiography is performed and coronary disease is confirmed, the benefits and risks of intensive antiplatelet therapy exist whether medical therapy or percutaneous coronary intervention is elected," said Stephen D. Wiviott, MD. Dr. Wiviott is a senior investigator with the TIMI Study Group, associate physician, Cardiovascular Division at Brigham and Women's Hospital, and associate professor of Medicine at Harvard Medical School.

The results of the TRILOGY ACS Angiographic Cohort trial will be presented on October 24 in Miami, Florida.


Story Source:

The above story is based on materials provided by Cardiovascular Research Foundation. Note: Materials may be edited for content and length.


Cite This Page:

Cardiovascular Research Foundation. "Prasugrel may reduce cardiovascular events among patients managed medically after an angiogram for acute coronary syndrome." ScienceDaily. ScienceDaily, 24 October 2012. <www.sciencedaily.com/releases/2012/10/121024141641.htm>.
Cardiovascular Research Foundation. (2012, October 24). Prasugrel may reduce cardiovascular events among patients managed medically after an angiogram for acute coronary syndrome. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2012/10/121024141641.htm
Cardiovascular Research Foundation. "Prasugrel may reduce cardiovascular events among patients managed medically after an angiogram for acute coronary syndrome." ScienceDaily. www.sciencedaily.com/releases/2012/10/121024141641.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins