Featured Research

from universities, journals, and other organizations

Immune system fighters speak in patterns of proteins, prefer squishy partners

Date:
October 26, 2012
Source:
AVS: Science & Technology of Materials, Interfaces, and Processing
Summary:
Researchers have discovered two new conditions for immune system communication that may help scientists one day harness the power of T-cells to fight diseases such as cancer.

When talking to the key immune system fighters known as T-cells, it helps to speak their language. Now researchers from Columbia University in New York, N.Y., and the University of Pennsylvania in Philadelphia have discovered two new conditions for communication that may help scientists one day harness the power of T-cells to fight diseases such as cancer.

The team will present its findings at the AVS 59th International Symposium and Exhibition, held Oct. 28 -- Nov. 2 in Tampa, Fla.

T-cells flow freely throughout the body and communicate with their partner T-cells, in part, through signals expressed in proteins on their surfaces. But unlike other freely circulating cells, T-cells are a bit more touchy-feely. "They stick to each other; they kind of crawl on each other," says lead researcher Lance Kam, a biomedical engineer at Columbia University. The cells spread onto each other; they put new proteins into the interface between them. And these proteins at the interface, Kam continues, "organize into some really beautiful patterns." One arrangement is shaped like a bulls-eye.

Kam's team wanted to find out whether the spacing of the proteins in these cellular tete-a-tetes plays a part in the communication process, and whether the squishiness or rigidity of the cells has any effect on the conversation. Using a custom-made artificial cell, they tested whether the real T-cells "liked" certain configurations of proteins on its surface. Not only did the team find that the spacing of the signaling proteins mattered for the proper activation of T-cells, but the rigidity of the surface mattered as well. Mouse cells -- like most cells -- preferred a more rigid surface, but human T-cells liked squishier partners.

Knowing that these two conditions figure into T-cell activation may help drug researchers design optimal T-cell habitats in which to grow huge T-cell armies to fight cancers and other diseases. While this reality is several years away, the two new findings that the team presents will help advance the harnessing of T-cells for immunotherapy. This type of cancer treatment involves removing a patient's T-cells, expanding their numbers, training them to recognize cancer cells, and re-injecting this fortified army back into the patient. Understanding what kind of partner the T-cells prefer could help to make this process more effective.

"We think that by learning more about the natural interface, the natural signals that activate the cells, we can get better control over the cell expansion process," Kam says, resulting in larger production of high-quality T-cells that can fight cancer.


Story Source:

The above story is based on materials provided by AVS: Science & Technology of Materials, Interfaces, and Processing. Note: Materials may be edited for content and length.


Cite This Page:

AVS: Science & Technology of Materials, Interfaces, and Processing. "Immune system fighters speak in patterns of proteins, prefer squishy partners." ScienceDaily. ScienceDaily, 26 October 2012. <www.sciencedaily.com/releases/2012/10/121026143216.htm>.
AVS: Science & Technology of Materials, Interfaces, and Processing. (2012, October 26). Immune system fighters speak in patterns of proteins, prefer squishy partners. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2012/10/121026143216.htm
AVS: Science & Technology of Materials, Interfaces, and Processing. "Immune system fighters speak in patterns of proteins, prefer squishy partners." ScienceDaily. www.sciencedaily.com/releases/2012/10/121026143216.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins