Featured Research

from universities, journals, and other organizations

Feedback loop maintains basal cell population

Date:
November 1, 2012
Source:
Baylor College of Medicine
Summary:
Notch -- the protein that can help determine cell fate -- maintains a stable population of basal cells in the prostate through a positive feedback loop system with another key protein -- TGF beta (transforming growth factor beta), said researchers.

Notch -- the protein that can help determine cell fate -- maintains a stable population of basal cells in the prostate through a positive feedback loop system with another key protein TGF beta (transforming growth factor beta), said Baylor College of Medicine researchers in the journal Cell Stem Cell.

"When basal cell homeostasis (or maintenance of a stable population) is disrupted, it may be part of the process that initiates prostate cancer," said Dr. Li Xin, assistant professor of molecular and cellular biology at BCM and a senior author of the report.

"Notch signaling takes different functions in different cell lineages," he said. "For example, Notch can suppress proliferation of basal cells and enhance it in luminal cells (another population of cells in the prostate)."

Disruption affects basal cells

In studies in mice, Xin and his colleagues found that disrupting the Notch signal did not have much effect on the basal cells. However, when they disrupted both Notch and TGF beta signal, the basal cells begin to proliferate a lot, he said.

Notch is one of the important parts of the process by which basal cells sense the signals from TGF beta, said Xin.

While it might be tempting to suppress Notch signaling in an effort to prevent prostate cancer, it is probably not the best course. Systemic long-term inhibition of Notch can be toxic to intestines and result in vascular tumors.

"Once the important layer of basal cells is laid down in the prostate, the Notch-TGF beta feedback loop keeps the homeostasis of basal cells in the adult mouse prostate," said Xin.

Could play role in prostate cancer

"The disruption of this layer of basal cells may play a critical role in the initiation of prostate cancer," said Xin.

He credits graduate student Joseph Valdez in his laboratory with doing much of the work. Valdez is first author on the report. Others from BCM who took part include Li Zhang, Qingtai Su, Olga Dakhova, Yiqun Zhang, Payam Shahi, David M. Spencer, Chad J. Creighton and Michael M. Ittmann.

Funding for this work came from the National Institutes of Health. Valdez is supported by a Research Supplement to Promote Diversity in Health-Related Research from the NIH.


Story Source:

The above story is based on materials provided by Baylor College of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. JosephM. Valdez, Li Zhang, Qingtai Su, Olga Dakhova, Yiqun Zhang, Payam Shahi, DavidM. Spencer, ChadJ. Creighton, MichaelM. Ittmann, Li Xin. Notch and TGFβ Form a Reciprocal Positive Regulatory Loop that Suppresses Murine Prostate Basal Stem/Progenitor Cell Activity. Cell Stem Cell, 2012; 11 (5): 676 DOI: 10.1016/j.stem.2012.07.003

Cite This Page:

Baylor College of Medicine. "Feedback loop maintains basal cell population." ScienceDaily. ScienceDaily, 1 November 2012. <www.sciencedaily.com/releases/2012/11/121101121540.htm>.
Baylor College of Medicine. (2012, November 1). Feedback loop maintains basal cell population. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2012/11/121101121540.htm
Baylor College of Medicine. "Feedback loop maintains basal cell population." ScienceDaily. www.sciencedaily.com/releases/2012/11/121101121540.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins