Featured Research

from universities, journals, and other organizations

Feedback loop maintains basal cell population

Date:
November 1, 2012
Source:
Baylor College of Medicine
Summary:
Notch -- the protein that can help determine cell fate -- maintains a stable population of basal cells in the prostate through a positive feedback loop system with another key protein -- TGF beta (transforming growth factor beta), said researchers.

Notch -- the protein that can help determine cell fate -- maintains a stable population of basal cells in the prostate through a positive feedback loop system with another key protein TGF beta (transforming growth factor beta), said Baylor College of Medicine researchers in the journal Cell Stem Cell.

Related Articles


"When basal cell homeostasis (or maintenance of a stable population) is disrupted, it may be part of the process that initiates prostate cancer," said Dr. Li Xin, assistant professor of molecular and cellular biology at BCM and a senior author of the report.

"Notch signaling takes different functions in different cell lineages," he said. "For example, Notch can suppress proliferation of basal cells and enhance it in luminal cells (another population of cells in the prostate)."

Disruption affects basal cells

In studies in mice, Xin and his colleagues found that disrupting the Notch signal did not have much effect on the basal cells. However, when they disrupted both Notch and TGF beta signal, the basal cells begin to proliferate a lot, he said.

Notch is one of the important parts of the process by which basal cells sense the signals from TGF beta, said Xin.

While it might be tempting to suppress Notch signaling in an effort to prevent prostate cancer, it is probably not the best course. Systemic long-term inhibition of Notch can be toxic to intestines and result in vascular tumors.

"Once the important layer of basal cells is laid down in the prostate, the Notch-TGF beta feedback loop keeps the homeostasis of basal cells in the adult mouse prostate," said Xin.

Could play role in prostate cancer

"The disruption of this layer of basal cells may play a critical role in the initiation of prostate cancer," said Xin.

He credits graduate student Joseph Valdez in his laboratory with doing much of the work. Valdez is first author on the report. Others from BCM who took part include Li Zhang, Qingtai Su, Olga Dakhova, Yiqun Zhang, Payam Shahi, David M. Spencer, Chad J. Creighton and Michael M. Ittmann.

Funding for this work came from the National Institutes of Health. Valdez is supported by a Research Supplement to Promote Diversity in Health-Related Research from the NIH.


Story Source:

The above story is based on materials provided by Baylor College of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Joseph M. Valdez, Li Zhang, Qingtai Su, Olga Dakhova, Yiqun Zhang, Payam Shahi, David M. Spencer, Chad J. Creighton, Michael M. Ittmann, Li Xin. Notch and TGFβ Form a Reciprocal Positive Regulatory Loop that Suppresses Murine Prostate Basal Stem/Progenitor Cell Activity. Cell Stem Cell, 2012; 11 (5): 676 DOI: 10.1016/j.stem.2012.07.003

Cite This Page:

Baylor College of Medicine. "Feedback loop maintains basal cell population." ScienceDaily. ScienceDaily, 1 November 2012. <www.sciencedaily.com/releases/2012/11/121101121540.htm>.
Baylor College of Medicine. (2012, November 1). Feedback loop maintains basal cell population. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2012/11/121101121540.htm
Baylor College of Medicine. "Feedback loop maintains basal cell population." ScienceDaily. www.sciencedaily.com/releases/2012/11/121101121540.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins