Featured Research

from universities, journals, and other organizations

New drug significantly lowers bad cholesterol

Date:
November 6, 2012
Source:
Brigham and Women's Hospital
Summary:
New research finds that AMG 145 added to statin therapy can reduce LDL cholesterol by up to 66 percent.

For many people with high cholesterol, statins serve as the first line of treatment. However, some patients are unable to effectively reduce their low-density lipoprotein cholesterol (LDL cholesterol) or "bad cholesterol" levels with statins, the most commonly used medication to treat high cholesterol, due to their bodies' inability to tolerate or sufficiently respond to the medicine.

Related Articles


Now researchers at Brigham and Women's Hospital have shown that in patients already on a statin, the addition of a new drug, called AMG 145, can reduce LDL cholesterol levels by up to 66 percent after 12 weeks.

The study was presented at the 2012 American Heart Association Scientific Sessions and electronically published in Lancet on November 6, 2012.

In a double-blind, dose-ranging, placebo-controlled study, 631 patients ages 18 to 80 years old with high cholesterol on a stable statin dose (with or without ezetimibe) were randomized to receive one of six different AMG 145 dose regimens or matching placebo. The treatments were given subcutaneously (an injection under the skin) every two or every four weeks for a total of twelve weeks.

In participants who received AMG 145 every two weeks, the drug reduced LDL cholesterol in a dose-dependent manner by 42 to 66 percent at the end of twelve weeks compared to placebo.

For those taking AMG 145 every four weeks, the drug reduced LDL cholesterol in a dose-dependent manner by 42 to 50 percent at the end of twelve weeks compared to placebo. Moreover, just one week after a dose, researchers saw LDL cholesterol reduced by up to 85 percent.

"The observed reductions in LDL cholesterol are extraordinary, especially when one considers that they are seen on top of statin therapy," said Robert Giugliano, MD, BWH Cardiovascular Division, Department of Medicine, investigator for the Thrombolysis in Myocardial Infarction (TIMI) Study Group, and lead study author.

The highest dose given every two weeks also allowed 93.5 percent of patients to achieve the most stringent cholesterol-lowering goals. Furthermore, the researchers noted that there were no serious adverse events that occurred with AMG 145 treatment.

"These data are very exciting and may offer a new paradigm for LDL cholesterol reduction. The next step will be a large-scale, long-term cardiovascular outcomes trial," said Marc Sabatine, MD, chairman of the TIMI Study Group, and senior study author.

AMG 145 is a monoclonal antibody. It binds to a protein that normally shepherds LDL cholesterol receptors for destruction. By blocking that protein, AMG 145 protects the receptors from being destroyed, thereby increasing the number of LDL cholesterol receptors on the surface of the liver that help remove bad cholesterol from the bloodstream.

This research was supported by Amgen, Inc., who participated in the study design and data collection. Data analyses were performed and interpreted independently by the TIMI Study Group, Brigham and Women's Hospital.


Story Source:

The above story is based on materials provided by Brigham and Women's Hospital. Note: Materials may be edited for content and length.


Journal Reference:

  1. Robert P Giugliano, Nihar R Desai, Payal Kohli, William J Rogers, Ransi Somaratne, Fannie Huang, Thomas Liu, Satishkumar Mohanavelu, Elaine B Hoffman, Shannon T McDonald, Timothy E Abrahamsen, Scott M Wasserman, Robert Scott, Marc S Sabatine. Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): a randomised, placebo-controlled, dose-ranging, phase 2 stu. The Lancet, 2012; DOI: 10.1016/S0140-6736(12)61770-X

Cite This Page:

Brigham and Women's Hospital. "New drug significantly lowers bad cholesterol." ScienceDaily. ScienceDaily, 6 November 2012. <www.sciencedaily.com/releases/2012/11/121106143541.htm>.
Brigham and Women's Hospital. (2012, November 6). New drug significantly lowers bad cholesterol. ScienceDaily. Retrieved March 27, 2015 from www.sciencedaily.com/releases/2012/11/121106143541.htm
Brigham and Women's Hospital. "New drug significantly lowers bad cholesterol." ScienceDaily. www.sciencedaily.com/releases/2012/11/121106143541.htm (accessed March 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com
Indiana Permits Needle Exchange as HIV Cases Skyrocket

Indiana Permits Needle Exchange as HIV Cases Skyrocket

Reuters - US Online Video (Mar. 26, 2015) Governor Mike Pence declares the recent HIV outbreak in rural Indiana a "public health emergency" and authorizes a short-term needle-exchange program. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com
AAA: Distracted Driving a Serious Teen Problem

AAA: Distracted Driving a Serious Teen Problem

AP (Mar. 25, 2015) While distracted driving is not a new problem for teens, new research from the AAA Foundation for Traffic Safety says it&apos;s much more serious than previously thought. (March 25) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins