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Pancreas stem cell discovery may lead to new diabetes treatments

Date:
November 14, 2012
Source:
Walter and Eliza Hall Institute
Summary:
Stem cells in the adult pancreas have been identified that can be turned into insulin producing cells, a finding that means people with type 1 diabetes might one day be able to regenerate their own insulin-producing cells.

Stem cells in the adult pancreas have been identified that can be turned into insulin producing cells, a finding that means people with type 1 diabetes might one day be able to regenerate their own insulin-producing cells.

The discovery was made by scientists from the Walter and Eliza Hall Institute and provides further evidence that stem cells don't only occur in the embryo.

The ability to produce the hormone insulin is crucial for controlling blood sugar (glucose) levels. In people with type 1 diabetes the body's immune system destroys the insulin-producing beta cells of the pancreas, leading to a potentially fatal elevation of blood glucose levels.

People with type 1 diabetes rely on multiple daily injections of insulin, or an insulin infusion pump, to control their blood glucose, but control is not perfect and they are at risk of serious long-term health complications.

Dr Ilia Banakh and Professor Len Harrison from the institute's Molecular Medicine division have not only identified and isolated stem cells from the adult pancreas, but developed a technique to drive these stem cells to become insulin-producing cells that can secrete insulin in response to glucose.

Professor Harrison said that insulin-producing cells had previously been generated from cells in the adult pancreas with 'stem cell-like' properties. "But what Dr Banakh has done is pinpoint the cell of origin of the insulin-producing cells and shown that the number of these cells and their ability to turn into insulin-producing cells increases in response to pancreas injury. This is exciting, because it means that the potential to regenerate insulin-producing cells is there in all of us, even as adults," Professor Harrison said.

"In the long-term, we hope that people with type 1 diabetes might be able to regenerate their own insulin-producing cells. This would mean that they could make their own insulin and regain control of their blood glucose levels, curing their diabetes. Of course, this strategy will only work if we can devise ways to overcome the immune attack on the insulin-producing cells, that causes diabetes in the first place," Professor Harrison said.

Professor Harrison is a clinician scientist whose research led to current clinical trials that could prevent type 1 diabetes. In recognition of his achievements, Diabetes Australia will tonight award Professor Harrison the Outstanding Contribution to Diabetes Award at its awards dinner marking World Diabetes Day.

The stem cell research, published this month in the journal PLOS One, was supported by the JDRF, the National Health and Medical Research Council of Australia and the Victorian Government.


Story Source:

The above story is based on materials provided by Walter and Eliza Hall Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ilia Banakh, Leonel J. Gonez, Robyn M. Sutherland, Gaetano Naselli, Leonard C. Harrison. Adult Pancreas Side Population Cells Expand after β Cell Injury and Are a Source of Insulin-Secreting Cells. PLoS ONE, 2012; 7 (11): e48977 DOI: 10.1371/journal.pone.0048977

Cite This Page:

Walter and Eliza Hall Institute. "Pancreas stem cell discovery may lead to new diabetes treatments." ScienceDaily. ScienceDaily, 14 November 2012. <www.sciencedaily.com/releases/2012/11/121114113452.htm>.
Walter and Eliza Hall Institute. (2012, November 14). Pancreas stem cell discovery may lead to new diabetes treatments. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2012/11/121114113452.htm
Walter and Eliza Hall Institute. "Pancreas stem cell discovery may lead to new diabetes treatments." ScienceDaily. www.sciencedaily.com/releases/2012/11/121114113452.htm (accessed April 18, 2014).

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