Featured Research

from universities, journals, and other organizations

Umbilical cord cells outperform bone marrow cells in repairing damaged hearts

Date:
November 15, 2012
Source:
University of Toronto
Summary:
A new study has shown that cells derived from the umbilical cord are more effective in restoring heart function after an acute myocardial infarction (in common parlance, a heart attack) in a pre-clinical model than a similar cell population derived from bone marrow.

A study published this month by researchers at the University of Toronto and Toronto's Princess Margaret Hospital has shown that cells derived from the umbilical cord, "Human Umbilical Cord PeriVascular Cells" (HUCPVCs), are more effective in restoring heart function after an acute myocardial infarction (in common parlance, a heart attack) in a pre-clinical model than a similar cell population derived from bone marrow.

Related Articles


At present, mesenchymal cells, known to release a series of factors that stimulate tissue repair, and control inflammation, are most commonly harvested from bone marrow. But the new study, headed by Dr. Armand Keating, now suggests that umbilical cord cells outperform bone marrow cells in improving heart muscle function.

The study, released in Cell Transplantation this month, demonstrates that the cells originating from the tissues surrounding the blood vessels of the human umbilical cord, also known as "Wharton's Jelly," outperformed the current gold standard for stem cell therapies for repairing damage to heart muscles, after an induced heart attack when injected directly into the affected area. Dr. Keating calls the HUCPVC results "statistically and significantly better" than bone marrow cells.

Standard heart function tests measured the effect of the therapy after the cells were injected. The HUCPVC cell therapy was twice as effective at repairing damage to heart tissue than no treatment.

"We are hoping that this translates into fewer people developing complications of heart failure because their muscle function after a heart attack is better," states Keating.

Keating and his team will now complete additional pre-clinical studies, and hope to begin clinical trials of the HUCPVC cells on patients within 12-18 months.

Keating is also interested in conducting further research with the umbilical cord cells to overcome the damaging effects of chemotherapy on heart tissue, an agonizing problem for some patients who may be cured of their cancer only to confront heart failure as a result of treatment.

Apart from heart disease, clinical trials with mesenchymal cells are conducted around the world to investigate the treatment of a variety of diseases, including a serious complication of bone marrow transplantation called graft-versus-host disease, autoimmune disorders, neurological diseases and tissue injury arising from lung and liver disease. Today, more than 250 clinical trials are currently being conducted worldwide using mesenchymal cells.


Story Source:

The above story is based on materials provided by University of Toronto. Note: Materials may be edited for content and length.


Cite This Page:

University of Toronto. "Umbilical cord cells outperform bone marrow cells in repairing damaged hearts." ScienceDaily. ScienceDaily, 15 November 2012. <www.sciencedaily.com/releases/2012/11/121115133706.htm>.
University of Toronto. (2012, November 15). Umbilical cord cells outperform bone marrow cells in repairing damaged hearts. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2012/11/121115133706.htm
University of Toronto. "Umbilical cord cells outperform bone marrow cells in repairing damaged hearts." ScienceDaily. www.sciencedaily.com/releases/2012/11/121115133706.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins