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Groundbreaking study may change transplant practices

Date:
November 20, 2012
Source:
John Theurer Cancer Center
Summary:
New research may change the current blood and marrow transplantation practices. The phase III, multicenter study compared harvesting stem cells from bone marrow rather than blood and suggests there are benefits to both approaches, but no survival differences between the two methods.

Researchers from John Theurer Cancer Center at Hackensack University Medical Center, one of the nation's 50 best cancer centers, played an important role in a study published in the New England Journal of Medicine on October 18 that may change the current blood and marrow transplantation practices. The phase 3, multicenter study compared harvesting stem cells from bone marrow rather than blood and suggests there are benefits to both approaches, but no survival differences between the two methods.

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Over the past 10 years, 75 percent of stem cell transplants from unrelated adult donors have used peripheral blood stem cells rather than those harvested from bone marrow without clinical data to support this shift. The study did not find significant survival differences between peripheral-blood stem-cell and bone marrow transplantation from unrelated donors.

"We did find that peripheral-blood stem cells may reduce the risk of graft failure, whereas bone marrow may reduce the risk of developing chronic graft-versus-host disease (GVHD), a complication that is frequently debilitating," said study author Scott Rowley, M.D., Chief, Blood and Marrow Transplantation at John Theurer Cancer Center.

GVHD is a common complication that can occur after a stem cell or bone marrow transplant in which the newly transplanted donor cells attack the transplant recipient's body. This can cause a variety of serious side effects, such as skin rashes, liver problems and diarrhea. Chronic GVHD usually starts three months after transplant and can last a lifetime. Its symptoms may include chronic pain, dry eyes and mouth, fatigue, skin rash, weight loss.

"As one of the 10 largest blood and marrow transplant programs in the nation, we remain committed to being on the forefront of the latest transplantation research and treatment," said Andrew L. Pecora, M.D., F.A.C.P., C.P.E., Chief Innovations Officer and Professor and Vice President of Cancer Services, John Theurer Cancer Center.


Story Source:

The above story is based on materials provided by John Theurer Cancer Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Claudio Anasetti, Brent R. Logan, Stephanie J. Lee, Edmund K. Waller, Daniel J. Weisdorf, John R. Wingard, Corey S. Cutler, Peter Westervelt, Ann Woolfrey, Stephen Couban, Gerhard Ehninger, Laura Johnston, Richard T. Maziarz, Michael A. Pulsipher, David L. Porter, Shin Mineishi, John M. McCarty, Shakila P. Khan, Paolo Anderlini, William I. Bensinger, Susan F. Leitman, Scott D. Rowley, Christopher Bredeson, Shelly L. Carter, Mary M. Horowitz, Dennis L. Confer. Peripheral-Blood Stem Cells versus Bone Marrow from Unrelated Donors. New England Journal of Medicine, 2012; 367 (16): 1487 DOI: 10.1056/NEJMoa1203517

Cite This Page:

John Theurer Cancer Center. "Groundbreaking study may change transplant practices." ScienceDaily. ScienceDaily, 20 November 2012. <www.sciencedaily.com/releases/2012/11/121120100419.htm>.
John Theurer Cancer Center. (2012, November 20). Groundbreaking study may change transplant practices. ScienceDaily. Retrieved March 1, 2015 from www.sciencedaily.com/releases/2012/11/121120100419.htm
John Theurer Cancer Center. "Groundbreaking study may change transplant practices." ScienceDaily. www.sciencedaily.com/releases/2012/11/121120100419.htm (accessed March 1, 2015).

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