Featured Research

from universities, journals, and other organizations

Mmolecular mechanisms leading to basal cell carcinoma initiation uncovered

Date:
November 26, 2012
Source:
Libre de Bruxelles, Université
Summary:
Researchers have uncovered the molecular mechanisms leading to basal cell carcinoma initiation. One of the most outstanding and unresolved questions in cancer biology is the identification of cells at the origin of cancer and the understanding of the molecular changes that occur in tumor initiating cells from the first oncogenic mutation to the development of invasive cancer.

One of the most outstanding and unresolved questions in cancer biology is the identification of cells at the origin of cancer and the understanding of the molecular changes that occur in tumor initiating cells from the first oncogenic mutation to the development of invasive cancer. Basal cell carcinoma (BCC) is the most frequent cancer in human with more than million of new patients diagnosed each year with BCCs.

Related Articles


Recently, the group of Pr. Cédric Blanpain uncovered the cells at the origin of BCC (Youssef et al, Nature Cell Biology, 2010).

In a new study published in advanced online publication of Nature Cell Biology, researchers lead by Cédric Blanpain, MD/PhD, Professor at Université libre de Bruxelles (ULB) and WELBIO investigator dissected for the first time the molecular changes occurring in basal cell carcinoma initiating cells from the first oncogenic mutation until the development of invasive cancer.

Khalil Kass Youssef and colleagues established the molecular signature of tumor initiating cells at different time during cancer initiation. They found that that cells at the origin of the basal cell carcinoma were progressively reprogrammed into embryonic hair follicle progenitor like fate before progressing into invasive carcinoma. "We were extremely surprised to see that tumor initiating cells were progressively and profoundly reprogram into a molecular identity that resemble to progenitor cells presented during embryonic development" comments Khalil Kass Youssef, the first author of this study.

In collaboration with bioinformaticians from the ULB and the KUL, the researchers demonstrate that Wnt/β-catenin signaling pathway is activated in BCC-initiating cells soon after oncogene expression. Using genetic or pharmacologic inhibition of the Wnt/β-catenin signaling, the researchers demonstrate that Wnt/beta-catenin signaling is essential for the reprograming of tumor initiating cells into embryonic hair follicle progenitors and for tumor initiation.

In collaboration with physicians from the Department of Dermatology, Pathology and Plastic Surgery from the Hospital Erasme, the group of Cédric Blanpain demonstrate that human BCCs also present signs of reprograming into embryonic hair follicle progenitors and activation of the Wnt/beta-catenin signaling, demonstrating the relevance of these findings for human patients.

This new work is at the frontier of multiple fields of biology and medicine and will be extremely important for researchers studying cancer, development, and stem cell biology. "I am particularly excited about this work, because this basic research turn out to be very relevant for human diseases, with the identification of potentially new avenues to treat or to prevent the occurrence of the most common cancer in humans " comments Pr Cédric Blanpain.

This work was supported by the FNRS, the program d'excellence CIBLES of the Wallonia Region, a research grant from the Fondation Contre le Cancer, the Fondation ULB, the Fond Yvonne Boël, the Fond Gaston Ithier, a starting grant of the European Research Council (ERC) and the EMBO Young Investigator Program.


Story Source:

The above story is based on materials provided by Libre de Bruxelles, Université. Note: Materials may be edited for content and length.


Journal Reference:

  1. Khalil Kass Youssef, Gaëlle Lapouge, Karine Bouvrée, Sandrine Rorive, Sylvain Brohée, Ornella Appelstein, Jean-Christophe Larsimont, Vijayakumar Sukumaran, Bram Van de Sande, Doriana Pucci, Sophie Dekoninck, Jean-Valery Berthe, Stein Aerts, Isabelle Salmon, Véronique del Marmol, Cédric Blanpain. Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation. Nature Cell Biology, 2012; DOI: 10.1038/ncb2628

Cite This Page:

Libre de Bruxelles, Université. "Mmolecular mechanisms leading to basal cell carcinoma initiation uncovered." ScienceDaily. ScienceDaily, 26 November 2012. <www.sciencedaily.com/releases/2012/11/121126110534.htm>.
Libre de Bruxelles, Université. (2012, November 26). Mmolecular mechanisms leading to basal cell carcinoma initiation uncovered. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2012/11/121126110534.htm
Libre de Bruxelles, Université. "Mmolecular mechanisms leading to basal cell carcinoma initiation uncovered." ScienceDaily. www.sciencedaily.com/releases/2012/11/121126110534.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins