Researchers at the University of Gothenburg, Sweden, and the Chalmers University of Technology, Sweden, demonstrate that an altered gut microbiota in humans is associated with symptomatic atherosclerosis and stroke.
These findings are presented in a study published Dec. 4 in Nature Communications.
The human body contains ten times more bacterial cells than human cells, most of which are found in the gut. These bacteria contain an enormous number of genes in addition to our host genome, and are collectively known as the gut metagenome.
Rapidly expanding field
How does the metagenome affect our health? This question is currently being addressed by researchers in the rapidly expanding field of metagenomic research. Several diseases have been linked to variations in the metagenome.
Researchers at Chalmers University of Technology and Sahlgrenska Academy, University of Gothenburg, now also show that changes in the gut metagenome can be linked to atherosclerosis and stroke.
Differences in gut microbiota
The researchers compared a group of stroke patients with a group of healthy subjects and found major differences in their gut microbiota. In particular, they showed that genes required for the production of carotenoids were more frequently found in gut microbiota from healthy subjects. The healthy subjects also had significantly higher levels of a certain carotenoid in the blood than the stroke survivors.
Affects disease states
Carotenoids are a type of antioxidant, and it has been claimed for many years that they protect against angina and stroke. Thus, the increased incidence of carotenoid-producing bacteria in the gut of healthy subjects may offer clues to explain how the gut metagenome affects disease states.
Carotenoids are marketed today as a dietary supplement. The market for them is huge, but clinical studies of their efficacy in protecting against angina and stroke have produced varying results.
Important health benefits
Jens Nielsen, Professor of Systems Biology at Chalmers, says that it may be preferable to take probiotics instead -- for example dietary supplements containing types of bacteria that produce carotenoids.
"Our results indicate that long-term exposure to carotenoids, through production by the bacteria in the digestive system, has important health benefits. These results should make it possible to develop new probiotics. We think that the bacterial species in the probiotics would establish themselves as a permanent culture in the gut and have a long-term effect."
Develop risk prognoses
"By examining the patient's bacterial microbiota, we should also be able to develop risk prognoses for cardiovascular disease," says Fredrik Bäckhed, Professor of Molecular Medicine at the University of Gothenburg,. "It should be possible to provide completely new disease-prevention options."
The researchers have now started a company, Metabogen, to further develop their discoveries relating to the metagenome. Their success is based on close cooperation between engineers, microbiologists and doctors.
Jens Nielsen and Fredrik Bäckhed both agree that one of the challenges in the rapidly developing area of metagenomics is its multidisciplinary facets, requiring novel collaborations and merging of research fields.
The research was funded by: Knut and Alice Wallenberg Foundation, the Chalmers Foundation, Swedish Heart Lung Foundation, Torsten Söderberg's Foundation, IngaBritt och Arne Lundbergs Foundation, AFA Insurances, the Swedish Research Council, and the Swedish Foundation for Strategic Research.
- Fredrik H. Karlsson, Frida Fåk, Intawat Nookaew, Valentina Tremaroli, Björn Fagerberg, Dina Petranovic, Fredrik Bäckhed, Jens Nielsen. Symptomatic atherosclerosis is associated with an altered gut metagenome. Nature Communications, 2012; 3: 1245 DOI: 10.1038/ncomms2266
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