Featured Research

from universities, journals, and other organizations

Cellular metabolism arms T cells to battle viruses and tumors

Date:
December 24, 2012
Source:
Trinity College Dublin
Summary:
New research demonstrates that the cellular metabolism of certain immune cells is closely linked to their function, which includes protecting against viral infections and the development of tumors. Results recently published reveal the relationship between glucose metabolism in Cytotoxic T lymphocytes (CTL) and their ability to acquire the tools necessary to migrate and kill virally infected cells or tumor cells.

New research demonstrates that the cellular metabolism of certain immune cells is closely linked to their function, which includes protecting against viral infections and the development of tumours.

Related Articles


Results recently published in the Journal of Experimental Medicine reveal the relationship between glucose metabolism in Cytotoxic T lymphocytes (CTL) and their ability to acquire the tools necessary to migrate and kill virally infected cells or tumour cells. CTL are generated in response to particular cues, which promote the acquisition of a range of cytotoxic tools that are used to kill target cells and provide the ability to migrate to the locations in the body where they are required, i.e. sites of inflammation. While glucose has often been considered simply as a fuel source, this work reveals that the nature of glucose metabolism in CTL is closely linked to key CTL functions.

"It was previously thought that high levels of glucose metabolism simply served to provide CTL with energy and the raw materials to facilitate cell growth," explains Dr Finlay, "but it is now clear that in CTL glucose metabolism can dictate the function of these important immune cells."

Dr David Finlay of the School of Biochemistry and Immunology, Trinity College Dublin, working with Prof Doreen Cantrell's laboratory in the University of Dundee, has established that the activities of two proteins, mTORC1 and HIF1•, are essential to maintain CTL glucose metabolism and normal CTL function. Disruption of mTORC1 or HIF1• dramatically reduces glucose utilisation in CTL while also disrupting the levels of key molecules that are required for normal migration and target cell killing. This work affords new insight into the relationship between cellular metabolism and cellular function in immune cells.

Inappropriate activation of CTL contributes to the pathology associated with a range of autoimmune diseases including Multiple Sclerosis and Rheumatoid Arthritis. Dr Finlay and Prof Cantrell's work reveals the potential for novel therapeutic strategies to disrupt CTL migration and cytotoxic function for the treatment autoimmune conditions.


Story Source:

The above story is based on materials provided by Trinity College Dublin. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. K. Finlay, E. Rosenzweig, L. V. Sinclair, C. Feijoo-Carnero, J. L. Hukelmann, J. Rolf, A. A. Panteleyev, K. Okkenhaug, D. A. Cantrell. PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells. Journal of Experimental Medicine, 2012; 209 (13): 2441 DOI: 10.1084/jem.20112607

Cite This Page:

Trinity College Dublin. "Cellular metabolism arms T cells to battle viruses and tumors." ScienceDaily. ScienceDaily, 24 December 2012. <www.sciencedaily.com/releases/2012/12/121224113420.htm>.
Trinity College Dublin. (2012, December 24). Cellular metabolism arms T cells to battle viruses and tumors. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2012/12/121224113420.htm
Trinity College Dublin. "Cellular metabolism arms T cells to battle viruses and tumors." ScienceDaily. www.sciencedaily.com/releases/2012/12/121224113420.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins