Featured Research

from universities, journals, and other organizations

Smaller radiation fields can spare brain when treating tumors, research finds

Date:
January 9, 2013
Source:
Wake Forest Baptist Medical Center
Summary:
New research shows that patients suffering from aggressive brain tumors can be effectively treated with smaller radiation fields to spare the rest of the brain and preserve cognition.

New research from Wake Forest Baptist Medical Center shows that patients suffering from aggressive brain tumors can be effectively treated with smaller radiation fields to spare the rest of the brain and preserve cognition.

Related Articles


"For patients with glioblastoma, we now know we can safely and effectively treat them with smaller radiation fields to spare the rest of their normal brain," said lead investigator Michael D. Chan, M.D., assistant professor of radiation oncology at Wake Forest Baptist. "That's important because it lessens the symptoms from radiation toxicity like tiredness and nausea."

Chan said that a patient's cognition is related to how much normal brain is irradiated so focusing radiation on smaller areas of the brain may help preserve cognition and does not seem to lead to an increase in the likelihood of the tumor recurring. Overall, while long-term survival rates for glioblastoma multiforme patients have not improved by much with treatment advances, the ability to treat with smaller radiation fields preserves cognition and provides the possibility of better quality of life.

Recent research findings from Chan and colleagues appeared online last month ahead of print in the American Journal of Clinical Oncology. While there have been other similar studies, this one is the largest to compare smaller radiation margins to larger ones to document differences in patterns of failure for patients, Chan said. For this retrospective study, records for 161 patients treated at Wake Forest Baptist over the last 10 years were reviewed.

"We decided a few years ago that it would be worthwhile to look at whether using these tighter margins would affect the tumors coming back outside of the radiation field, or tell us if we are barely missing," Chan said. "We are the first to show definitively that people with smaller margins don't do any worse than those with larger margins."

Chan said that in the 1990s, Wake Forest Baptist's Edward G. Shaw, M.D., professor of radiation oncology, was part of a group that pioneered using smaller margins because it was less toxic. Smaller radiation margins around the tumor do not seem to lead to an increase in the tumor returning just outside of the radiation field, Chan said. A smaller radiation field, combined with modern treatment techniques, like newer chemotherapy agents and radiation technologies, provides physicians with more options.

"Treatments have gotten better over time and people with GBM may live longer than they had in the past. Our study found that the margins did not affect where the GBM came back or how long it took it to come back and it did not affect the overall survival," Chan said. "This could potentially be practice changing."

Co-authors include: Anna K. Paulsson, B.S., Kevin P. McMullen, M.D., Ann M. Pfeiffer, Ph.D., William H. Hinson, PhD., William T. Kearns, M.S., Annette J. Johnson, M.D., M.S., Glenn J. Lesser, M.D., Thomas L. Ellis, M.D., Stephen B. Tatter, M.D., Ph.D., Waldemar Debinski, M.D., Ph.D., and Edward G. Shaw, M.D., M.A., all of Wake Forest Baptist.


Story Source:

The above story is based on materials provided by Wake Forest Baptist Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Anna K. Paulsson, Kevin P. McMullen, Ann M. Peiffer, William H. Hinson, William T. Kearns, Annette J. Johnson, Glenn J. Lesser, Thomas L. Ellis, Stephen B. Tatter, Waldemar Debinski, Edward G. Shaw, Michael D. Chan. Limited Margins Using Modern Radiotherapy Techniques Does Not Increase Marginal Failure Rate of Glioblastoma. American Journal of Clinical Oncology, 2012; DOI: 10.1097/COC.0b013e318271ae03

Cite This Page:

Wake Forest Baptist Medical Center. "Smaller radiation fields can spare brain when treating tumors, research finds." ScienceDaily. ScienceDaily, 9 January 2013. <www.sciencedaily.com/releases/2013/01/130109124231.htm>.
Wake Forest Baptist Medical Center. (2013, January 9). Smaller radiation fields can spare brain when treating tumors, research finds. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2013/01/130109124231.htm
Wake Forest Baptist Medical Center. "Smaller radiation fields can spare brain when treating tumors, research finds." ScienceDaily. www.sciencedaily.com/releases/2013/01/130109124231.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins