Featured Research

from universities, journals, and other organizations

Clinical trial of medication to treat NF2 tumors starting soon

Date:
February 12, 2013
Source:
House Research Institute
Summary:
Researchers are recruiting patients for a Phase II clinical trial to test a medication that may slow the progression of Neurofibromatosis Type-2, commonly referred to as NF2.

Mouse schwannoma cell in culture.
Credit: Image courtesy of House Research Institute

House Research Institute (HRI) is recruiting patients for a Phase II clinical trial to test a medication that may slow the progression of Neurofibromatosis Type-2, commonly referred to as NF2.

Related Articles


NF2 is a genetic disease characterized by noncancerous tumors in the central nervous system. The disease occurs in 1 in 25,000 births in the United States. A diagnosis of NF2 is made when tumors, called vestibular schwannomas or acoustic neuromas, are found on both auditory nerves. The growth of the tumors can lead to hearing loss, facial paralysis and balance difficulties because the tumors are located on the auditory, balance, and facial nerves. When the tumors are surgically removed, patients are often left completely deaf.

"With few treatment options available other than surgery for patients with NF2, we often watch the tumors and wait as long as possible before operating. Although surgery removes the tumor, we often have to cut the patient's auditory nerve leaving the patient deaf in that ear," said Derald Brackmann, M.D., House Clinic Associate and Co-Investigator.

The clinical trial is investigating the medication RAD001 (everolimus), an analog of Rapamycin, to see if the drug is effective in slowing the growth of the vestibular schwannomas in NF2 patients. The pre-clinical research results are promising.

"It was an exciting moment when we first saw the potential effect of this drug on NF2 tumors in our preclinical NF2 mouse model. It is a good candidate for clinical trials in humans," said Marco Giovannini, M.D., Ph.D., House Research Institute Principal Investigator.

To be eligible to participate in the study, patients must have at least one vestibular schwannoma, which has shown growth in the prior 12 month time period. Patients must also be between 16 and 65 years-old. Up to 25 patients will be enrolled in the clinical trial.

"It is a privilege to work with world leaders in the NF2 field to bring this molecular targeted therapy to patients," said Joni Doherty, M.D., Ph.D., House Research Institute Co-Investigator.

The study consists of taking RAD001 orally for 12 months or until the tumor shows growth. Tumor growth will be monitored with several MRI scans throughout the 12 months of the study.

In addition to the primary objective of the trial, the secondary objective is to see if RAD001 slows the growth of other central nervous system tumors the patients may have and to see if the patients experience any changes in their hearing.

For more information on the clinical trial, please visit http://clinicaltrials.gov/show/NCT01345136.


Story Source:

The above story is based on materials provided by House Research Institute. Note: Materials may be edited for content and length.


Cite This Page:

House Research Institute. "Clinical trial of medication to treat NF2 tumors starting soon." ScienceDaily. ScienceDaily, 12 February 2013. <www.sciencedaily.com/releases/2013/02/130212111729.htm>.
House Research Institute. (2013, February 12). Clinical trial of medication to treat NF2 tumors starting soon. ScienceDaily. Retrieved February 27, 2015 from www.sciencedaily.com/releases/2013/02/130212111729.htm
House Research Institute. "Clinical trial of medication to treat NF2 tumors starting soon." ScienceDaily. www.sciencedaily.com/releases/2013/02/130212111729.htm (accessed February 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, February 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Newsy (Feb. 26, 2015) People who sleep more than eight hours per night are 45 percent more likely to have a stroke, according to a University of Cambridge study. Video provided by Newsy
Powered by NewsLook.com
London Show Dissects History of Forensic Science

London Show Dissects History of Forensic Science

AFP (Feb. 25, 2015) Forensic science, which has fascinated generations with its unravelling of gruesome crime mysteries, is being put under the microscope in an exhibition of real criminal investigations in London. Duration: 00:53 Video provided by AFP
Powered by NewsLook.com
Michigan Couple Celebrates Identical Triplets

Michigan Couple Celebrates Identical Triplets

AP (Feb. 25, 2015) A suburban Detroit couple who have two older children are adjusting to life after becoming parents to identical triplets _ a multiple birth a doctor calls rare. (Feb. 25) Video provided by AP
Powered by NewsLook.com
Mayor Says District of Columbia to Go Ahead With Pot Legalization

Mayor Says District of Columbia to Go Ahead With Pot Legalization

Reuters - News Video Online (Feb. 25, 2015) Washington&apos;s mayor says the District of Columbia will move forward with marijuana legalization, despite pushback from Congress. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins