Featured Research

from universities, journals, and other organizations

Variations in four genes associated with increased risk of colorectal cancer

Date:
February 20, 2013
Source:
Fred Hutchinson Cancer Research Center
Summary:
Medical researchers have identified variations in four genes that are linked to an increased risk of colorectal cancer.

An international research team co-led by cancer prevention researcher Ulrike "Riki" Peters, Ph.D., M.P.H., and biostatistician Hsu Li, Ph.D., at Fred Hutchinson Cancer Research Center has identified variations in four genes that are linked to an increased risk of colorectal cancer.

Related Articles


Peters and colleagues from 40 institutes throughout the world published their findings online ahead of the April print issue of Gastroenterology.

Peters and colleagues for the past four years have been studying the genes linked to colorectal cancer through the Genetics and Epidemiology of Colorectal Cancer Consortium, a collaboration involving researchers from North America, Australia and Europe who have pooled data from approximately 40,000 study participants, about half of whom have colorectal cancer. Fred Hutch houses GECCO's coordinating center and Peters is its principal investigator.

The genomewide-association study was conducted in two phases. The first involved rapidly scanning complete sets of blood DNA from 12,696 people with colorectal cancer or a precancerous condition called adenoma. This data was then compared to the same set of variants from 15,113 healthy controls of European descent.

Of 2.7 million genetic variants identified, the 10 most statistically significant mutations associated with colorectal cancer were then further analyzed in a follow-up genomewide-association study of 3,056 colorectal cancers or adenomas and colon-tissue samples from 6,658 healthy controls of European and Asian descent.

The research team uncovered mutations in the following genes -- all genetic variants that previously had not been associated with colorectal cancer: NABP -- a gene involved in DNA repair LAMC1 -- the second gene in the laminin gene family found to be associated with colorectal cancer CCND2 -- a gene involved in cell-cycle control, which is a key control mechanism to prevent cancer development TBX3 -- a gene transcription factor that targets a known colorectal cancer pathway If a person carries one or two copies of any of these genetic variants, their risk of colorectal cancer is increased by 10 percent to 40 percent compared to a person who does not harbor such DNA genetic variants, Peters said.

"These findings could potentially lead to new drug targets and, in combination with previously identified genetic and environmental risk factors, identify subgroups of the population that can benefit most from colorectal-cancer screening and could be targeted for early or more frequent endoscopy, a very effective screening tool for colorectal cancer," said Peters, a member of the Public Health Sciences Division at Fred Hutch.

GECCO is funded by the National Cancer Institute, the National Institutes of Health and the U.S. Department of Health and Human Services.


Story Source:

The above story is based on materials provided by Fred Hutchinson Cancer Research Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ulrike Peters, Shuo Jiao, Fredrick R. Schumacher, Carolyn M. Hutter, Aaron K. Aragaki, John A. Baron, Sonja I. Berndt, Stéphane Bézieau, Hermann Brenner, Katja Butterbach, Bette J. Caan, Peter T. Campbell, Christopher S. Carlson, Graham Casey, Andrew T. Chan, Jenny Chang–Claude, Stephen J. Chanock, Lin S. Chen, Gerhard A. Coetzee, Simon G. Coetzee, David V. Conti, Keith R. Curtis, David Duggan, Todd Edwards, Charles S. Fuchs, Steven Gallinger, Edward L. Giovannucci, Stephanie M. Gogarten, Stephen B. Gruber, Robert W. Haile, Tabitha A. Harrison, Richard B. Hayes, Brian E. Henderson, Michael Hoffmeister, John L. Hopper, Thomas J. Hudson, David J. Hunter, Rebecca D. Jackson, Sun Ha Jee, Mark A. Jenkins, Wei–Hua Jia, Laurence N. Kolonel, Charles Kooperberg, Sébastien Küry, Andrea Z. LaCroix, Cathy C. Laurie, Cecelia A. Laurie, Loic Le Marchand, Mathieu Lemire, David Levine, Noralane M. Lindor, Yan Liu, Jing Ma, Karen W. Makar, Keitaro Matsuo, Polly A. Newcomb, John D. Potter, Ross L. Prentice, Conghui Qu, Thomas Rohan, Stephanie A. Rosse, Robert E. Schoen, Daniela Seminara, Martha Shrubsole, Xiao–ou Shu, Martha L. Slattery, Darin Taverna, Stephen N. Thibodeau, Cornelia M. Ulrich, Emily White, Yongbing Xiang, Brent W. Zanke, Yi–Xin Zeng, Ben Zhang, Wei Zheng, Li Hsu. Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-wide Meta-analysis. Gastroenterology, 2012; DOI: 10.1053/j.gastro.2012.12.020

Cite This Page:

Fred Hutchinson Cancer Research Center. "Variations in four genes associated with increased risk of colorectal cancer." ScienceDaily. ScienceDaily, 20 February 2013. <www.sciencedaily.com/releases/2013/02/130220134722.htm>.
Fred Hutchinson Cancer Research Center. (2013, February 20). Variations in four genes associated with increased risk of colorectal cancer. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2013/02/130220134722.htm
Fred Hutchinson Cancer Research Center. "Variations in four genes associated with increased risk of colorectal cancer." ScienceDaily. www.sciencedaily.com/releases/2013/02/130220134722.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Adults Only Get The Flu Twice A Decade, Researchers Say

Adults Only Get The Flu Twice A Decade, Researchers Say

Newsy (Mar. 4, 2015) — Researchers found adults only get the flu about once every five years. Scientists analyzed how a person&apos;s immunity builds up over time as well. Video provided by Newsy
Powered by NewsLook.com
New Hormone Could Protect Against Diabetes And Weight Gain

New Hormone Could Protect Against Diabetes And Weight Gain

Newsy (Mar. 4, 2015) — A newly discovered hormone mimics the effects of exercise, protecting against diabetes and weight gain. Video provided by Newsy
Powered by NewsLook.com
Mount Everest Has a Poop Problem

Mount Everest Has a Poop Problem

Buzz60 (Mar. 4, 2015) — With no bathrooms to use, climbers of Mount Everest have been leaving human waste on the mountain for years, and it&apos;s becoming a health issue. Mike Janela (@mikejanela) has more. Video provided by Buzz60
Powered by NewsLook.com
The Best Tips to 'Skinny' Your Home

The Best Tips to 'Skinny' Your Home

Buzz60 (Mar. 4, 2015) — If you&apos;re looking to reach your health goals this season, there are a few simple tips to help you spring clean your space and improve your nutrition. Krystin Goodwin (@krystingoodwin) has the skinny on keeping a healthy home. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins