Featured Research

from universities, journals, and other organizations

Tiny tweezers and their big influence on bustling proteins: Scientists investigate molecular 'clothespins'

Date:
February 22, 2013
Source:
Max-Planck-Institut für Kohlenforschung
Summary:
Tiny molecular tweezers have a remarkable impact on bustling proteins: Scientists have found that molecular tweezers can be used to regulate protein-protein interactions by selectively trapping certain residues of the protein -- and stick like a clothespin.

The molecular tweezers can be used to regulate protein - protein interactions by selectively trapping certain residues of the protein.
Credit: Image courtesy of Max-Planck-Institut für Kohlenforschung

Tiny molecular tweezers have a remarkable impact on bustling proteins: Three research groups from the University of Duisburg-Essen (UDE), the Chemical Genomics Centre of the Max Planck Society in Dortmund and the Max Planck Institut für Kohlenforschung in Mülheim found that the molecular tweezers designed by Professor Frank Klärner at the UDE can be used to regulate protein -- protein interactions by selectively trapping certain residues of the protein -- and stick like a clothespin.

Related Articles


The research groups of Thomas Schrader (UDE), Christian Ottmann (Chemical Genomics Centre) and Elsa Sanchez Garcia (MPI für Kohlenforschung) believe that this might be a promising approach for applications in medical research, as the water soluble tweezers act without inducing toxicity or explicit side effects.

The scientists have tested their small tweezers on proteins that have influence on many processes in the human body. "We also wanted to know how they work," says Dr. Elsa Sanchez Garcia, leader of a Max Planck research group at the Max Planck Institut für Kohlenforschung. The chemists have found out that although their tweezers prefer to bind at the amino acid lysine, the protein surrounding of the lysine influences the trapping of the tweezers. Thus, with computer simulations Dr. Sanchez Garcia and her colleague Kenny Bravo Rodriguez have shown which type of lysine the tweezers prefer -- and why that is the case. Their work also allowed to lay down rules for predicting the behavior of the tweezers in the presence of proteins with several lysine residues.

Although the tweezers research is at early stages, their potentiality makes it worth for medical researchers to have a closer look at these results. The 14-3-3 adapter proteins (14-3-3) that the scientists used for their experiments are small recognition proteins that influence many physiological processes by binding their targets via short peptide sequences and modulating their function. For instance, they are able to stabilize certain tumor suppressors. Because of their important role in many biological processes, 14-3-3 proteins are prospective therapeutic agents against severe disorders, such as cancer.

The three research groups published their findings in the Nature Chemistry.


Story Source:

The above story is based on materials provided by Max-Planck-Institut für Kohlenforschung. Note: Materials may be edited for content and length.


Journal Reference:

  1. David Bier, Rolf Rose, Kenny Bravo-Rodriguez, Maria Bartel, Juan Manuel Ramirez-Anguita, Som Dutt, Constanze Wilch, Frank-Gerrit Klärner, Elsa Sanchez-Garcia, Thomas Schrader, Christian Ottmann. Molecular tweezers modulate 14-3-3 protein–protein interactions. Nature Chemistry, 2013; 5 (3): 234 DOI: 10.1038/nchem.1570

Cite This Page:

Max-Planck-Institut für Kohlenforschung. "Tiny tweezers and their big influence on bustling proteins: Scientists investigate molecular 'clothespins'." ScienceDaily. ScienceDaily, 22 February 2013. <www.sciencedaily.com/releases/2013/02/130222102648.htm>.
Max-Planck-Institut für Kohlenforschung. (2013, February 22). Tiny tweezers and their big influence on bustling proteins: Scientists investigate molecular 'clothespins'. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2013/02/130222102648.htm
Max-Planck-Institut für Kohlenforschung. "Tiny tweezers and their big influence on bustling proteins: Scientists investigate molecular 'clothespins'." ScienceDaily. www.sciencedaily.com/releases/2013/02/130222102648.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Matter & Energy News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) — A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Building Google Into Cars

Building Google Into Cars

Reuters - Business Video Online (Dec. 19, 2014) — Google's next Android version could become the standard that'll power your vehicle's entertainment and navigation features, Reuters has learned. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
AP Review: Nikon D750 and GoPro Hero 4

AP Review: Nikon D750 and GoPro Hero 4

AP (Dec. 19, 2014) — What to buy an experienced photographer or video shooter? There is some strong gear on the market from Nikon and GoPro. The AP's Ron Harris takes a closer look. (Dec. 19) Video provided by AP
Powered by NewsLook.com
Obama: Better Ways to Create Jobs Than Keystone Pipeline

Obama: Better Ways to Create Jobs Than Keystone Pipeline

AFP (Dec. 19, 2014) — US President Barack Obama says that construction of the Keystone pipeline would have 'very little impact' on US gas prices and believes there are 'more direct ways' to create construction jobs. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins