Featured Research

from universities, journals, and other organizations

Cell sugar concentrations affect hyaluronan production and cancer growth

Date:
February 27, 2013
Source:
University of Eastern Finland
Summary:
According to a recent study, elevated cell sugar concentrations increase the production of hyaluronan which, in turn, promotes cancer growth. Regulating the production of hyaluronan may be a way to prevent the spreading of cancer. Hyaluronan is a long, linear carbohydrate polymer present in the human body. It forms a coating on the surface of many cells and plays a key role in fetal development and in the maintenance of normal tissue balance. Under normal circumstances, hyaluronan promotes tissue healing; however, it can also maintain inflammation and promote the growth of cancer cells.

According to a recent University of Eastern Finland (UEF) study, elevated cell sugar concentrations increase the production of hyaluronan which, in turn, promotes cancer growth. Regulating the production of hyaluronan may be a way to prevent the spreading of cancer.

Hyaluronan is a long, linear carbohydrate polymer present in the human body. It forms a coating on the surface of many cells and plays a key role in fetal development and in the maintenance of normal tissue balance. Under normal circumstances, hyaluronan promotes tissue healing; however, it can also maintain inflammation and promote the growth of cancer cells. Due to its high water retention capacity, hyaluronan is widely used in cosmetics and also in the medical sector, for example in the treatment of osteoarthritis symptoms and in eye surgery. Hyaluronan injected into the human body for treatment purposes is not associated with cancer risk.

Cells produce hyaluronan with the help of three cell membrane enzymes (HAS1, HAS2 and HAS3), and the production process also needs glucose derivatives.. Hyaluronan synthase 1, i.e. the HAS1 enzyme, is the least well known of the hyaluronan-producing enzymes, and yet its role in cancer malignity seems to be greater than previously thought. Published in Journal of Biological Chemistry, the UEF study showed that HAS1 requires a higher sugar concentration for the production of hyaluronan than HAS2 and HAS3. This finding may be significant for fighting cancer, as cancer cells are known to thrive on blood glucose. Increased glucose levels can lead to increased production of hyaluronan which, in turn, promotes cancer growth. Increased hyaluronan levels have also been found in diabetics with increased blood sugar levels. Diabetics are known to have a higher risk for breast cancer.

HAS1 also plays a significant role in inflammation, because growth factors associated with inflammation mediation, e.g., interleukins, can increase its activeness. This finding constituted part of the doctoral study of Lic. Med. Hanna Siiskonen, which was recently examined at the University of Eastern Finland. By regulating hyaluronan levels, it may be possible to prevent the progression of cancer and other pathologies. The first clinical trials involving enzymes which break down hyaluronan have been able to slow down the growth and movement of cancer cells and to enhance the effectiveness of cancer drugs.


Story Source:

The above story is based on materials provided by University of Eastern Finland. Note: Materials may be edited for content and length.


Journal Reference:

  1. K. Rilla, S. Oikari, T. A. Jokela, J. M. T. Hyttinen, R. Karna, R. H. Tammi, M. I. Tammi. Hyaluronan Synthase 1 (HAS1) Requires Higher Cellular UDP-GlcNAc Concentration than HAS2 and HAS3. Journal of Biological Chemistry, 2013; 288 (8): 5973 DOI: 10.1074/jbc.M112.443879

Cite This Page:

University of Eastern Finland. "Cell sugar concentrations affect hyaluronan production and cancer growth." ScienceDaily. ScienceDaily, 27 February 2013. <www.sciencedaily.com/releases/2013/02/130227085832.htm>.
University of Eastern Finland. (2013, February 27). Cell sugar concentrations affect hyaluronan production and cancer growth. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2013/02/130227085832.htm
University of Eastern Finland. "Cell sugar concentrations affect hyaluronan production and cancer growth." ScienceDaily. www.sciencedaily.com/releases/2013/02/130227085832.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com
What's To Blame For Worst Ebola Outbreak In History?

What's To Blame For Worst Ebola Outbreak In History?

Newsy (July 27, 2014) A U.S. doctor has tested positive for the deadly Ebola virus, as the worst-ever outbreak continues to grow. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins