Featured Research

from universities, journals, and other organizations

Kala-azar treatment failing in Nepal

Date:
February 28, 2013
Source:
Institute of Tropical Medicine Antwerp
Summary:
In a recent study, scientists have concluded that the cure rates of Miltefosine, the only oral drug for visceral leishmaniasis available, have significantly decreased. Miltefosine was introduced in the Indian subcontinent a decade ago. Despite adhering to the treatment, only 3 out of 4 patients treated with Miltefosine in Nepal today are being cured.

In a recent study, scientists have concluded that the cure rates of Miltefosine, the only oral drug for visceral leishmaniasis available, have significantly decreased. Miltefosine was introduced in the Indian subcontinent a decade ago. Despite adhering to the treatment, only 3 out of 4 patients treated with Miltefosine in Nepal today are being cured.

Related Articles


Visceral leishmaniasis, also known as 'kala-azar', is the most severe form of leishmaniasis and fatal if not treated. The disease is the second-largest parasitic killer in the world, after malaria, and is endemic in the Indian subcontinent, East Africa, Latin America and Southern Europe. Early diagnosis and treatment are essential to save patients' lives, and to control the spreading of the disease.

There are very few drugs available to counter this neglected infectious disease. By the end of the 20th century, the kala-azar parasite showed such an increased resistance to injectable antimonial drugs that its use had to be abandoned on the Indian subcontinent.

When Miltefosine was first introduced as part of a regional campaign in the Indian subcontinent for kala-azar elimination a decade ago, the drug proved to be very effective. The recent study shows that this effectiveness has now decreased significantly in Nepal.

The scientists used two methods to check whether the patients truly took the drug, but found that they adequately adhered to the treatment. They also explored whether drug-resistance could explain this high treatment failure, but so far no Miltefosine-resistant parasites were detected in patients. This suggests that other mechanisms causing a reduction in the efficacy of Miltefosine may be at work.

"These results constitute an alarming signal for the kala-azar elimination campaign. Drug policies should be reviewed to achieve better cure rates and to protect the few available drugs. We are now investigating among other things what role super-parasites -very well adapted to manipulate human immune protection- may play and whether they are somehow responsible for the reduced efficacy of Miltefosine " said Jean-Claude Dujardin, coordinator of the Kaladrug-R project at the Institute of Tropical Medicine in Antwerp and senior author of the study.

The paper 'Increasing failure of miltefosine in the treatment of kala-azar in Nepal and the potential role of parasite drug resistance, re-infection or non-compliance' is published in the latest issue of Clinical Infectious Diseases. The study is a collaboration between scientists from Nepal, the Netherlands and Belgium and part of a larger project, called 'Kaladrug-R', funded by the European Commission.


Story Source:

The above story is based on materials provided by Institute of Tropical Medicine Antwerp. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Rijal, B. Ostyn, S. Uranw, K. Rai, N. R. Bhattarai, T. P. C. Dorlo, J. H. Beijnen, M. Vanaerschot, S. Decuypere, S. S. Dhakal, M. L. Das, P. Karki, R. Singh, M. Boelaert, J.-C. Dujardin. Increasing failure of miltefosine in the treatment of kala-azar in Nepal and the potential role of parasite drug resistance, re-infection or non-compliance. Clinical Infectious Diseases, 2013; DOI: 10.1093/cid/cit102

Cite This Page:

Institute of Tropical Medicine Antwerp. "Kala-azar treatment failing in Nepal." ScienceDaily. ScienceDaily, 28 February 2013. <www.sciencedaily.com/releases/2013/02/130228103337.htm>.
Institute of Tropical Medicine Antwerp. (2013, February 28). Kala-azar treatment failing in Nepal. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2013/02/130228103337.htm
Institute of Tropical Medicine Antwerp. "Kala-azar treatment failing in Nepal." ScienceDaily. www.sciencedaily.com/releases/2013/02/130228103337.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Pot-Infused Edibles Raise Concerns in Colorado

Pot-Infused Edibles Raise Concerns in Colorado

AFP (Oct. 30, 2014) Colorado may have legalized marijuana for recreational use, but the debate around the decision still continues, with a recent - failed - attempt to ban cannabis-infused edibles. Duration: 01:53 Video provided by AFP
Powered by NewsLook.com
British Navy Ship Arrives in Sierra Leone With Ebola Aid

British Navy Ship Arrives in Sierra Leone With Ebola Aid

AFP (Oct. 30, 2014) The British ship RFA ARGUS arrived in Sierra Leone to deliver supplies and equipment to help the fight against Ebola. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins