Featured Research

from universities, journals, and other organizations

Virus and genes involved in causation of schizophrenia

Date:
March 8, 2013
Source:
Aarhus University
Summary:
For the first time, researchers have found that a combination of a particular virus in the mother and a specific gene variant in the child increases the risk of the child developing schizophrenia.

Viruses and genes interact in a way that may increase the risk of developing schizophrenia significantly. This happens already in the developing fetus.

Related Articles


An international team of scientists led by Aarhus University, Denmark, has made this discovery. As the first in the world, they scanned the entire genome of hundreds of sick and healthy people to see if there is an interaction between genes and a very common virus -- cytomegalovirus -- and to see whether the interaction influences the risk of developing schizophrenia.

And it does.

Women that have been infected by the virus -- and around 70 % has -- will have a statistically significant increased risk of giving birth to a child who later develops schizophrenia if the child also has the aforementioned gene variant. This variant is found in 15 percent. The risk is five times higher than usual, the researchers report in Molecular Psychiatry.

No cause for alarm

People infected with cytomegalovirus most often do not know it, as the infection by the virus, which belongs to the herpes virus family, is usually very mild. But the researchers stress that there is no cause for alarm -- even if both risk factors are present in mother and child, there may be a variety of other factors that prevents disease development in the child.

But as schizophrenia affects 1 per cent of the global population, this new knowledge is very important.

"In the longer term, the development of an effective vaccine against cytomegalovirus may help to prevent many cases of schizophrenia," says Professor of Medical Genetics at Aarhus University, Anders Børglum.

"And our discovery emphasizes that mental disorders such as schizophrenia may arise in the context of an interaction between genes and biological environmental factors very early in life."


Story Source:

The above story is based on materials provided by Aarhus University. Note: Materials may be edited for content and length.


Journal Reference:

  1. A D Børglum, D Demontis, J Grove, J Pallesen, M V Hollegaard, C B Pedersen, A Hedemand, M Mattheisen, A Uitterlinden, M Nyegaard, T Ørntoft, C Wiuf, M Didriksen, M Nordentoft, M M Nöthen, M Rietschel, R A Ophoff, S Cichon, R H Yolken, D M Hougaard, P B Mortensen, O Mors. Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci. Molecular Psychiatry, 2013; DOI: 10.1038/mp.2013.2

Cite This Page:

Aarhus University. "Virus and genes involved in causation of schizophrenia." ScienceDaily. ScienceDaily, 8 March 2013. <www.sciencedaily.com/releases/2013/03/130308111315.htm>.
Aarhus University. (2013, March 8). Virus and genes involved in causation of schizophrenia. ScienceDaily. Retrieved January 29, 2015 from www.sciencedaily.com/releases/2013/03/130308111315.htm
Aarhus University. "Virus and genes involved in causation of schizophrenia." ScienceDaily. www.sciencedaily.com/releases/2013/03/130308111315.htm (accessed January 29, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Thursday, January 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Binge-Watching TV Linked To Loneliness

Binge-Watching TV Linked To Loneliness

Newsy (Jan. 29, 2015) — Researchers at University of Texas at Austin found a link between binge-watching TV shows and feelings of loneliness and depression. Video provided by Newsy
Powered by NewsLook.com
Signs You Might Be The Passive Aggressive Friend

Signs You Might Be The Passive Aggressive Friend

BuzzFeed (Jan. 28, 2015) — "No, I&apos;m not mad. Why, are you mad?" Video provided by BuzzFeed
Powered by NewsLook.com
City Divided: A Look at Model Schools in the TDSB

City Divided: A Look at Model Schools in the TDSB

The Toronto Star (Jan. 27, 2015) — Model schools are rethinking how they engage with the community to help enhance the lives of the students and their parents. Video provided by The Toronto Star
Powered by NewsLook.com
Man Saves Pennies For 65 Years

Man Saves Pennies For 65 Years

Rooftop Comedy (Jan. 26, 2015) — A man in Texas saved every penny he found for 65 years, and this week he finally cashed them in. Bank tellers at Prosperity Bank in Slaton, Texas were shocked when Ira Keys arrived at their bank with over 500 pounds of loose pennies stored in coffee cans. After more than an hour of sorting and counting, it turned out the 81 year-old was in possession of 81,600 pennies, or $816. And he&apos;s got more at home! Video provided by Rooftop Comedy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins