Featured Research

from universities, journals, and other organizations

Immune finding aids quest for vaccines to beat tropical infections

Date:
March 14, 2013
Source:
University of Edinburgh
Summary:
Scientists are a step closer to developing vaccines for a range of diseases that affect 200 million people, mainly in tropical Southeast Asia, Africa and Central America.

Scientists are a step closer to developing vaccines for a range of diseases that affect 200 million people, mainly in tropical south-east Asia, Africa and Central America.

Researchers studying infections caused by parasitic worms -- which can lead to diseases such as elephantiasis and river blindness -- have shown how these can shut down a part of the immune system that might otherwise fight sickness. Preventing this immune reaction enables the infection to persist, causing chronic illness.

Scientists have also shown how this immune response can be re-activated to fight invading parasites, and enable the immune system to develop natural resistance to infection.

Their findings could help inform the development of vaccines for these types of infections. They also point towards potential treatments for allergies, which occur when the same part of the immune system over-reacts to irritants.

Researchers looked at a part of the immune system that responds to parasite infections, in a study of mice. They found that when infection begins, cells that would normally launch a counter-attack on the invading parasite -- and in so doing, help develop immunity -- become dormant.

They found that blocking the action of a tiny molecule attached to the surface of the cell reactivates the cell, and enables a fresh attack on the infection. Scientists hope to investigate the reaction further to determine whether it applies to people and animals such as livestock.

The study, published in PLOS Pathogens, was funded by the Medical Research Council and the Wellcome Trust.

Dr Matt Taylor of the University of Edinburgh's School of Biological Sciences, who led the study, said: "Understanding the intricacies of the immune system is a major goal in being able to control disease. This discovery brings us a step closer to explaining how long-term infections occur -- and how we might, in time, be able to tackle them."


Story Source:

The above story is based on materials provided by University of Edinburgh. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nienke van der Werf, Stephen A. Redpath, Miyuki Azuma, Hideo Yagita, Matthew D. Taylor. Th2 Cell-Intrinsic Hypo-Responsiveness Determines Susceptibility to Helminth Infection. PLoS Pathogens, 2013; 9 (3): e1003215 DOI: 10.1371/journal.ppat.1003215

Cite This Page:

University of Edinburgh. "Immune finding aids quest for vaccines to beat tropical infections." ScienceDaily. ScienceDaily, 14 March 2013. <www.sciencedaily.com/releases/2013/03/130314180147.htm>.
University of Edinburgh. (2013, March 14). Immune finding aids quest for vaccines to beat tropical infections. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2013/03/130314180147.htm
University of Edinburgh. "Immune finding aids quest for vaccines to beat tropical infections." ScienceDaily. www.sciencedaily.com/releases/2013/03/130314180147.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins