Featured Research

from universities, journals, and other organizations

Harnessing immune cells' adaptability to design an effective HIV vaccine

Date:
March 21, 2013
Source:
Cell Press
Summary:
In infected individuals, HIV mutates rapidly to escape recognition by immune cells. This process of evolution is the main obstacle to natural immunity and the development of an effective vaccine. A new study reveals that the immune system has the capacity to adapt such that it can recognize mutations in HIV.

In infected individuals, HIV mutates rapidly to escape recognition by immune cells. This process of continuous evolution is the main obstacle to natural immunity and the development of an effective vaccine. A new study published by Cell Press in the March 21 issue of the journal Immunity reveals that the immune system has the capacity to adapt such that it can recognize mutations in HIV.

Related Articles


The findings suggest that our immune cells' adaptability could be harnessed to help in the fight against AIDS.

An international collaboration between research groups in France, England, Japan, and Australia discovered that immune cells from certain infected individuals were able to recognize HIV mutants. Researchers found that the immune cells' ability to recognize such mutant forms of the virus was associated with a protective response against HIV. This discovery begs the question: if mutant HIV can be recognized by immune cells, how then does HIV often escape immune detection? The researchers explain that the answer lies in HIV's ability to conceal itself from immune surveillance altogether. It does so by blocking infected cells from breaking down its viral particles and from then displaying them on the cells' surface to alert the immune system.

"Using a spectrum of advanced immune profiling techniques, our work illustrates the sophisticated mechanisms that underlie the continuous competition, or 'molecular arms race,' between immune cells and HIV," says senior author Dr. Victor Appay, of Hôpital Pitié-Salpêtrière in Paris. "Overall, our study reveals the intricacies of immune cell efficacy against HIV."

Although immune cells not be able to recognize every mutant HIV, a vaccine that stimulates immune cells that recognize certain key mutant forms of the virus may be effective against viral infection and the development of AIDS.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kristin Ladell, Masao Hashimoto, Maria Candela Iglesias, Pascal G. Wilmann, James E. McLaren, Stéphanie Gras, Takayuki Chikata, Nozomi Kuse, Solène Fastenackels, Emma Gostick, John S. Bridgeman, Vanessa Venturi, Zaïna Aït Arkoub, Henri Agut, David J. van Bockel, Jorge R. Almeida, Daniel C. Douek, Laurence Meyer, Alain Venet, Masafumi Takiguchi, Jamie Rossjohn, David A. Price, Victor Appay. A Molecular Basis for the Control of Preimmune Escape Variants by HIV-Specific CD8 T Cells. Immunity, 2013; 38 (3): 425 [link]

Cite This Page:

Cell Press. "Harnessing immune cells' adaptability to design an effective HIV vaccine." ScienceDaily. ScienceDaily, 21 March 2013. <www.sciencedaily.com/releases/2013/03/130321133106.htm>.
Cell Press. (2013, March 21). Harnessing immune cells' adaptability to design an effective HIV vaccine. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2013/03/130321133106.htm
Cell Press. "Harnessing immune cells' adaptability to design an effective HIV vaccine." ScienceDaily. www.sciencedaily.com/releases/2013/03/130321133106.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins