Featured Research

from universities, journals, and other organizations

C. diff infection risk rises with antihistamine use to treat stomach acid

Date:
March 27, 2013
Source:
Mayo Clinic
Summary:
Patients receiving antihistamines to suppress stomach acid are at greater risk of infection from Clostridium difficile, or C. diff, a common cause of diarrhea, particularly in health care settings, researchers have found.

Patients receiving antihistamines to suppress stomach acid are at greater risk of infection from Clostridium difficile, or C. diff, a common cause of diarrhea, particularly in health care settings, Mayo Clinic researchers have found. The study focused on histamine 2 receptor antagonists. The researchers found no significant risk for people taking over-the-counter antihistamine drugs, however.

The findings appear in the online journal PLoS ONE.

Researchers reviewed 35 observations based on 33 separate studies involving C. diff and antihistamines used for stomach acid suppressive therapy. The researchers found a clear association between histamine 2 receptor antagonists use and C. diff infection. They say it was especially pronounced and caused the greatest risk for hospitalized patients receiving antibiotics. "It's not clear why these antihistamines increase the risk of C. diff infection, because gastric acid does not affect C. diff spores," says senior author Larry Baddour, M.D., a Mayo infectious diseases expert. "However, it may be that vegetative forms of C.diff, which are normally killed by stomach acid, survive due to use of stomach acid suppressors and cause infection."

Researchers say the study highlights the need for judicious use of histamine 2 receptor antagonists in hospitalized patients, and that reducing the use of these drugs could significantly reduce the risk of C. diff infections.

Co-authors include Imad M. Tleyjeh, M.D., M.Sc.; Muhammad Riaz, M.Sc.; Musa Garbati, M.D.; Mohamad Al-Tannir, DMD, MPH; Faisal Alasmari, M.D.; Mushabab AlGhamdi, M.D.; all of King Fahad Medical City; Aref Bin Abdulhak, M.D.; University of Missouri -- Kansas City; Abdur Rahman Khan, M.D.; Toledo Medical Center; Patricia Erwin, M.L.S, and Imad M. Tleyjeh, M.D.; M.Sc., Mayo Clinic; and Alex Sutton, Ph.D.; University of Leicester.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Journal Reference:

  1. Imad M. Tleyjeh, Aref A. Bin. Abdulhak, Muhammad Riaz, Musa A. Garbati, Mohamad Al-Tannir, Faisal A. Alasmari, Mushabab AlGhamdi, Abdur Rahman Khan, Patricia J. Erwin, Alex J. Sutton, Larry M. Baddour. The Association between Histamine 2 Receptor Antagonist Use and Clostridium difficile Infection: A Systematic Review and Meta-analysis. PLoS ONE, 2013; 8 (3): e56498 DOI: 10.1371/journal.pone.0056498

Cite This Page:

Mayo Clinic. "C. diff infection risk rises with antihistamine use to treat stomach acid." ScienceDaily. ScienceDaily, 27 March 2013. <www.sciencedaily.com/releases/2013/03/130327131310.htm>.
Mayo Clinic. (2013, March 27). C. diff infection risk rises with antihistamine use to treat stomach acid. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2013/03/130327131310.htm
Mayo Clinic. "C. diff infection risk rises with antihistamine use to treat stomach acid." ScienceDaily. www.sciencedaily.com/releases/2013/03/130327131310.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
New Drug Could Reduce Cardiovascular Deaths

New Drug Could Reduce Cardiovascular Deaths

Newsy (Aug. 30, 2014) The new drug from Novartis could reduce cardiovascular deaths by 20 percent compared to other similar drugs. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins