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C. diff infection risk rises with antihistamine use to treat stomach acid

Date:
March 27, 2013
Source:
Mayo Clinic
Summary:
Patients receiving antihistamines to suppress stomach acid are at greater risk of infection from Clostridium difficile, or C. diff, a common cause of diarrhea, particularly in health care settings, researchers have found.

Patients receiving antihistamines to suppress stomach acid are at greater risk of infection from Clostridium difficile, or C. diff, a common cause of diarrhea, particularly in health care settings, Mayo Clinic researchers have found. The study focused on histamine 2 receptor antagonists. The researchers found no significant risk for people taking over-the-counter antihistamine drugs, however.

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The findings appear in the online journal PLoS ONE.

Researchers reviewed 35 observations based on 33 separate studies involving C. diff and antihistamines used for stomach acid suppressive therapy. The researchers found a clear association between histamine 2 receptor antagonists use and C. diff infection. They say it was especially pronounced and caused the greatest risk for hospitalized patients receiving antibiotics. "It's not clear why these antihistamines increase the risk of C. diff infection, because gastric acid does not affect C. diff spores," says senior author Larry Baddour, M.D., a Mayo infectious diseases expert. "However, it may be that vegetative forms of C.diff, which are normally killed by stomach acid, survive due to use of stomach acid suppressors and cause infection."

Researchers say the study highlights the need for judicious use of histamine 2 receptor antagonists in hospitalized patients, and that reducing the use of these drugs could significantly reduce the risk of C. diff infections.

Co-authors include Imad M. Tleyjeh, M.D., M.Sc.; Muhammad Riaz, M.Sc.; Musa Garbati, M.D.; Mohamad Al-Tannir, DMD, MPH; Faisal Alasmari, M.D.; Mushabab AlGhamdi, M.D.; all of King Fahad Medical City; Aref Bin Abdulhak, M.D.; University of Missouri -- Kansas City; Abdur Rahman Khan, M.D.; Toledo Medical Center; Patricia Erwin, M.L.S, and Imad M. Tleyjeh, M.D.; M.Sc., Mayo Clinic; and Alex Sutton, Ph.D.; University of Leicester.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Journal Reference:

  1. Imad M. Tleyjeh, Aref A. Bin. Abdulhak, Muhammad Riaz, Musa A. Garbati, Mohamad Al-Tannir, Faisal A. Alasmari, Mushabab AlGhamdi, Abdur Rahman Khan, Patricia J. Erwin, Alex J. Sutton, Larry M. Baddour. The Association between Histamine 2 Receptor Antagonist Use and Clostridium difficile Infection: A Systematic Review and Meta-analysis. PLoS ONE, 2013; 8 (3): e56498 DOI: 10.1371/journal.pone.0056498

Cite This Page:

Mayo Clinic. "C. diff infection risk rises with antihistamine use to treat stomach acid." ScienceDaily. ScienceDaily, 27 March 2013. <www.sciencedaily.com/releases/2013/03/130327131310.htm>.
Mayo Clinic. (2013, March 27). C. diff infection risk rises with antihistamine use to treat stomach acid. ScienceDaily. Retrieved March 4, 2015 from www.sciencedaily.com/releases/2013/03/130327131310.htm
Mayo Clinic. "C. diff infection risk rises with antihistamine use to treat stomach acid." ScienceDaily. www.sciencedaily.com/releases/2013/03/130327131310.htm (accessed March 4, 2015).

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