Featured Research

from universities, journals, and other organizations

Weight loss surgery not only shrinks waists but also affects genes

Date:
April 11, 2013
Source:
Cell Press
Summary:
Gastric bypass surgery can drastically reduce the body weight of obese individuals in a short timeframe. For reasons that are not entirely clear, the surgery also leads to early remission of type 2 diabetes in the vast majority of patients.

Gastric bypass surgery can drastically reduce the body weight of obese individuals in a short timeframe. For reasons that are not entirely clear, the surgery also leads to early remission of type 2 diabetes in the vast majority of patients. Researchers report online April 11 in Cell Reports, published by Cell Press, the discovery of gene-expression alterations in individuals who underwent the surgery compared with obese individuals who did not.

"We provide evidence that in severely obese people, the levels of specific genes that control how fat is burned and stored in the body are changed to reflect poor metabolic health," says senior author Professor Juleen Zierath, of the Karolinska Institutet, in Stockholm, Sweden. "After surgery, the levels of these genes are restored to a healthy state, which mirrors weight loss and coincides with overall improvement in metabolism."

When the investigators probed deeper, they found that weight loss after surgery causes changes in DNA modifications that control gene expression in response to the environment. Specifically, changes in methylation, or chemical markings, on two genes that control glucose and fat metabolism (called PGC-1alpha and PDK4) correlate with obesity but are reversed after surgery-induced weight loss. The findings suggest that the environment -- in this case food intake or weight loss -- can affect gene expression through this mechanism.

"The novelty of our work originates with the finding that DNA methylation is altered by weight loss." says first author Romain Barrθs, of the University of Copenhagen, in Denmark.

The findings may be useful for the design of new drugs that mimic this weight-loss-associated control of gene regulation.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Romain Barres, Henriette Kirchner, Morten Rasmussen, Jie Yan, Francisc R. Kantor, Anna Krook, Erik Nδslund, Juleen R. Zierath. Weight Loss after Gastric Bypass Surgery in Human Obesity Remodels Promoter Methylation. Cell Reports, 11 April 2013 DOI: 10.1016/j.celrep.2013.03.018

Cite This Page:

Cell Press. "Weight loss surgery not only shrinks waists but also affects genes." ScienceDaily. ScienceDaily, 11 April 2013. <www.sciencedaily.com/releases/2013/04/130411123845.htm>.
Cell Press. (2013, April 11). Weight loss surgery not only shrinks waists but also affects genes. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2013/04/130411123845.htm
Cell Press. "Weight loss surgery not only shrinks waists but also affects genes." ScienceDaily. www.sciencedaily.com/releases/2013/04/130411123845.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) — A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com
How The 'Angelina Jolie Effect' Increased Cancer Screenings

How The 'Angelina Jolie Effect' Increased Cancer Screenings

Newsy (Sep. 19, 2014) — Angelina's Jolie's decision to undergo a preventative mastectomy in 2013 inspired many women to seek early screenings for the disease. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins